IL1B
Interleukin-1 beta (IL-1β) also known as '"leukocytic pyrogen"', "'leukocytic endogenous mediator'", "'mononuclear cell factor'", "'lymphocyte activating factor'" and other names, is a cytokine protein that in humans is encoded by the IL1B gene. There are two genes for Interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.
Function
The fever-producing property of human leukocytic pyrogen (Interleukin 1) was purified by Dinarello in 1977 (PNAS) with a specific activity of 10-20 nanograms/kg. In 1979, Dinarello reported that purified human leukocytic pyrogen was the same molecule that was described by Igal Gery in 1972. He named it lymphocyte-activating factor (LAF) because it was a lymphocyte mitogen. It was not until 1984 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta.
IL-1β is a member of the interleukin 1 family of cytokines. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Podcasts:
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Part of Me
by: Eli LiebDays like this I want to drive away
Pack my bags and watch your shadow fade
You chewed me up, you spit me out
Like I was poison in your mouth
You took my light, you drained me down
That was then and this is now
This is that part of me
That you're never gonna
Ever take away from me no
This is that part of me
That you're never gonna
Ever take away from me no
Throw your sticks and your stones
Throw your bombs and your blows
But you're not gonna break my soul
This is that part of me
That you're never gonna
Ever take away from me no
I just wanna throw my phone away
Find out who is really there for me
You ripped me off, your love was cheap
Always tearing at the seams
I fell deep, you let me drown
That was then and this is now, now look at me
This is that part of me
That you're never gonna
Ever take away from me no
This is that part of me
That you're never gonna
Ever take away from me no
Throw your sticks and your stones
Throw your bombs and your blows
But you're not gonna break my soul
This is that part of me
That you're never gonna
Ever take away from me no
Now look at me I'm sparkling
A firework, a dancing flame
You won't ever pull me out again I'm glowing, no
You can keep the diamond ring
It don't mean nothing anyway
In fact you can keep everything, yeah, yeah, except for me
This is that part of me
That you're never gonna
Ever take away from me no
This is that part of me
That you're never gonna
Ever take away from me no
Throw your sticks and your stones
Throw your bombs and your blows
But you're not gonna break my soul
This is that part of me
That you're never gonna
Ever take away from me no
Throw your sticks and your stones
Throw your bombs and your blows
But you're not gonna break my soul
This is that part of me
That you're never gonna