IL18RAP

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.

Function

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.

Disease association

Variants at IL18RAP have been linked to susceptibility to Coeliac disease.

See also

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.