IAPP
IAPP may refer to:
Amylin
Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.
IAPP is processed from an 89-residue coding sequence. Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.
Synthesis
ProIAPP consists of 67 amino acids, which follow a 22 amino acid signal peptide which is rapidly cleaved after translation of the 89 amino acid coding sequence. The human sequence (from N-terminus to C-terminus) is:
(MGILKLQVFLIVLSVALNHLKA) TPIESHQVEKR^ KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYG^ KR^ NAVEVLKREPLNYLPL.
Once released from the signal peptide, it undergoes additional proteolysis and posttranslational modification (indicated by ^). 11 amino acids are removed from the N-terminus by the enzyme proprotein convertase 2 (PC2) while 16 are removed from the C-terminus of the proIAPP molecule by proprotein convertase 1/3 (PC1/3). At the C-terminus Carboxypeptidase E then removes the terminal lysine and arginine residues. The terminal glycine amino acid that results from this cleavage allows the enzyme peptidylglycine alpha-amidating monooxygenase (PAM) to add an amine group. Finally, a disulfide bond is formed between cysteine residues numbers 2 and 7. After this the transformation from the precursor protein proIAPP to the biologically active IAPP is complete (IAPP sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY).
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Back Up
by: WebbieGirl you're too sexy
come and sit with me in V.I.P.
With those curves and cocoa skin
now where have you been
The tattoo on your belly's kinda hot
them about a shorty in the spot
You came in with a man
but I'm making plaaans
to be next to you
been checking out the rest and they just wont do
pretty young thing in a lexus coupe
been praying everyday to blessed with you (blessed with you)
but I am next to you
all I think about is undressing you
playing all alone just to touch with you
can we get it on in my bedroom
would ya mind
would ya mind
if I got to know ya better baby
your my type
and I really really want you lady so
make up your mind
do you want him or do you want me
take your time
its alright, I dont mind
I see ya checking out my rings and the platinum watch
your trying to figure out what I'm not
the keys to my range around my neck
and a legit royalty check
if ya looking for someone who has nice things
someone to give ya all the love you need
look no further I'm that man
and I got a plaaan
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind
stop wasting time
baby its alright
would ya mind
I wanna take ya home
get ya all alone
turn the lights down low
to a private show
kiss ya from head to toe
take off all your clothes
throw em on the floor
make a video
baby come stay awhile
you cant deny
what ya feel inside
its in your eyes
make up your mind
Latest News for: iapp
IAPP celebrates 25th anniversary in Portsmouth in age of AI
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