Interstate 264 is the designation for two Interstate Highways in the United States, both of which are related to Interstate 64:
Interstate 264 (abbreviated I-264) is an Interstate Highway in the U.S. state of Virginia. It runs from a junction with Interstate 64 and Interstate 664 (Hampton Roads Beltway) near Bowers Hill in Chesapeake east into Portsmouth and through the Downtown Tunnel under the South Branch Elizabeth River into Norfolk. At the Interstate 464 interchange in the Berkley section of Norfolk, I-264 turns north, crossing the East Branch Elizabeth River into downtown Norfolk on the Berkley Bridge, one of a small number of drawbridges on the Interstate Highway System. I-264 then heads east through Norfolk, crossing Interstate 64 at the east side of the Hampton Roads Beltway, and into Virginia Beach, where it ends at Parks Avenue just short of the Atlantic Ocean. From this point, 21st and 22nd streets continue as a one-way pair with no route designation to U.S. Route 60 (Pacific Avenue).
The original section of I-264, designated in the late 1950s, lies between the two I-64 junctions. The piece east to the Virginia Beach waterfront was built as the Virginia Beach-Norfolk Expressway (a toll road until 1995), and carried State Route 44 until I-264 was extended over it in 1999.
Interstate 264 is a loop around the south side of the city of Louisville, Kentucky. A child route of I-64, it is signed as the Georgia Davis Powers Expressway for its first eight miles from its western terminus at I-64/US-150 to US-31W/US-60; and as the Henry Watterson Expressway for the remainder of its length from US-31W/US-60 to its northeastern terminus at I-71. It is 22.93 miles (36.90 km) in length, and runs an open circle around central Louisville, Kentucky. The highway begins four miles (6 km) west of downtown at I-64 just east of the Sherman Minton Bridge which links Southern Indiana with Kentucky as it crosses the Ohio River. The interstate ends approximately six miles northeast of downtown Louisville, where it connects to I-71.
Louisville is one of few U.S. cities with two Interstate Highways serving as inner and outer beltways. I-264 is Louisville's inner beltway (in conjunction with I-64 and I-71) and the later constructed I-265, the Gene Snyder Freeway, is Louisville's outer beltway. I-264 is used as the primary detour route when Interstate 64 is closed through Downtown Louisville.