I22 may refer to:
I 22 is a Swedish regimental designation (22nd Infantry Regiment) that has been used by the following units:
Interstate 22 (I-22) is an Interstate highway that follows the U.S. Route 78 (US 78) corridor on a 213-mile-long (343 km) route from Memphis, Tennessee, to Birmingham, Alabama. I-22 indirectly connects I-240, I-40, I-55, and I-69 in the northwest with I-65 and I-20/I-59 in the southeast. Hence, I-22 helps form a freeway to connect downtown Atlanta with Birmingham, Memphis, Little Rock, Fort Smith, and Oklahoma City.
Along its way through the two states, I-22 serves the towns of Jasper, Winfield, and Hamilton, Alabama and Fulton, Tupelo, New Albany, and Holly Springs, Mississippi. All portions of this highway were either built new or converted to Interstate Highway standards as of early 2011. A future interchange with I-269 near Byhalia, Mississippi is the western terminus of I-22. As of December 2015, the eastern terminus is at Coalburg Road (County Route 77, CR 77), in Jefferson County, with the future eastern terminus being at an interchange with I-65 near Birmingham.