IB

IB, Ib or ib may refer to:

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Business and economics

Products and services

Interstate 895 (Maryland)

Interstate 895 (I-895) is an Interstate Highway in the U.S. state of Maryland. Known as the Harbor Tunnel Thruway, the highway runs 14.87 miles (23.93 km) between one junction with I-95 in Elkridge and another interchange with I-95 on the east side of Baltimore. I-895 is a toll road that crosses the Patapsco River estuary via the Baltimore Harbor Tunnel, connecting U.S. Route 1 (US 1), I-695, and the Baltimore–Washington Parkway in the southwestern suburbs of Baltimore with US 40 on the east side of Baltimore. In conjunction with a pair of spurs, unsigned I-895A and I-895B, I-895 provides access to the tunnel from I-97 and Maryland Route 2 (MD 2) in Glen Burnie. The highway is designed for through traffic by having partial interchanges that require vehicles from almost all starting points to pass through the tunnel and the tunnel toll plaza, where a $4 toll is charged to passenger vehicles, before exiting the facility.

NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Discovery

NF-κB was discovered by Dr. Ranjan Sen in the lab of Nobel Prize laureate David Baltimore via its interaction with an 11-base pair sequence in the immunoglobulin light-chain enhancer in B cells.

Structure