Hypnotize

Hypnotize may refer to:

Audioslave (album)

Audioslave is the eponymous debut studio album by the American rock supergroup Audioslave and was released on November 19, 2002 (see 2002 in music). It features the hit singles "Cochise", "Show Me How to Live", "What You Are", "Like a Stone", and "I Am the Highway". The record was certified triple platinum in the US. "Like a Stone" was nominated for the 2004 Grammy Award for Best Hard Rock Performance.

Background

Audioslave was formed after Zack de la Rocha left Rage Against the Machine and the remaining members were searching for another vocalist. Producer and friend Rick Rubin suggested that they contact Chris Cornell. Rubin played the remaining Rage Against the Machine band members the Soundgarden song "Slaves & Bulldozers" to showcase his ability. Cornell was in the writing process of a second solo album, but decided to shelve that and pursue the opportunity to work with Tom Morello, Tim Commerford and Brad Wilk when they approached him. Morello described Cornell: "He stepped to the microphone and sang the song and I couldn't believe it. It didn't just sound good. It sounded transcendent. And... when there is an irreplaceable chemistry from the first moment, you can't deny it." The quartet wrote 21 songs during 19 days of rehearsal and began working in the studio in late May 2001.

Hypnotize (System of a Down song)

"Hypnotize" is the lead single for Armenian American rock band System of a Down's album of the same name, which was released on November 22, 2005 (see 2005 in music). The video was filmed on September 28, 2005, at the Van Andel Arena in Grand Rapids, Michigan. It reached number one on Billboard's Hot Modern Rock Tracks chart and is the band's biggest international hit.

As in many Mezmerize/Hypnotize songs, guitarist Daron Malakian accompanies Serj Tankian in the vocal sections. Serj and Daron perform a harmony in the refrain before and after the instrumental bridge. The combination of the two vocalists gives the song a vocal range, with Serj handling the lower verses and Daron handling the higher verses. Musically, "Hypnotize" changes modes in several places. The opening guitar riff and early verses are an upbeat melody that switches between the I (melodic) and V (Hindu) modes of F# melodic minor. The later riffs and the outro to the song are in the more commonly heard VI (natural) mode of F# minor. This mixing of modes creates the song's characteristic psychedelic feeling.

BTK

BTK may refer to:

Biology

Business

Music

Other

Birth Through Knowledge

Birth Through Knowledge (aka BTK) was a Canadian hip-hop/rock band best known for their 1998 single "Peppyrock," the video for which was nominated for the 1998 MuchMusic Best Video Award. The band consisted of Lo-Ki (vocals), Stone Groove (vocals), DJ Spinz (turntables), Adam Carlo (bass),Sam Cino (drums,percussion) and Matt deMatteo (drums).

After signing onto the Tommyboy/Ignition label, BTK released one album "Birth Thru Knowledge" in 1998.

BTK first came to attention when their song "Corncob Pipe" was included on the sampler disc that Korn released alongside Follow the Leader. They were the first indie band to ever open the main-stage at Edgefest '97. In 1998, the band toured with the Beastie Boys and with Our Lady Peace. They appeared in the 1998 Summersault tour.

The band won the 1997 MuchMusic Best Independent Video Award for "Superchile." They were also nominated for a Juno Award in 1999 in the Best Alternative Album category, losing to Rufus Wainwright.

Footnotes

Bruton's tyrosine kinase

Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.

Function

BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.

Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP₂, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.

Clinical significance

Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.