Hyperoside is a chemical compound. It is the 3-O-galactoside of quercetin.
Hyperoside has been isolated from Drosera rotundifolia, from the Lamiaceae Stachys sp. and Prunella vulgaris, from Rumex acetosella, Cuscuta chinensis seeds, from St John’s wort and from Camptotheca acuminata. It is one of the phenolic compounds in the invasive plant Carpobrotus edulis and contributes to the antibacterial and antioxidant properties of the plant.
In Rheum nobile and R. rhaponticum, it serves as a UV blocker found in the bracts.
It is also found in Geranium niveum and Taxillus kaempferi.
It can have a protective antioxidant effect on cultured PC12 cells.
Like various other flavonoids, hyperoside has been found to possess antagonist activity at the κ-opioid receptor.