| Hydrogen voltage-gated channel 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | HVCN1; HV1; VSOP | ||||||||||||
| External IDs | OMIM: 611227 MGI: 1921346 HomoloGene: 12535 IUPHAR: Hv1 GeneCards: HVCN1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 84329 | 74096 | |||||||||||
| Ensembl | ENSG00000122986 | ENSMUSG00000064267 | |||||||||||
| UniProt | Q96D96 | Q3U2S8 | |||||||||||
| RefSeq (mRNA) | NM_001040107.1 | NM_001042489.1 | |||||||||||
| RefSeq (protein) | NP_001035196.1 | NP_001035954.1 | |||||||||||
| Location (UCSC) | Chr 12: 111.07 – 111.14 Mb |
Chr 5: 122.66 – 122.69 Mb |
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| PubMed search | [1] | [2] | |||||||||||
The HVCN1 gene codes for a voltage-gated proton channel that has been shown to allow proton transport into phagosomes[1][2] and out of many types of cells including spermatozoa, electrically excitable cells and respiratory epithelial cells.[3] The proton-conducting HVCN1 channel has only transmembrane domains corresponding to the S1-S4 voltage sensing domains (VSD) of voltage-gated potassium channels and voltage-gated sodium channels.[4] Molecular simulation is consistent with a water-filled pore that can function as a "water wire" for allowing hydrogen bonded H+ to cross the membrane.[5][6] The HVCN1 protein has been shown to exist as a dimer with two functioning pores.[7][8] Like other VSD channels, HVCN1 channels conduct ions about 1000-fold slower than channels formed by tetrameric S5-S6 central pores.[9]
References [link]
- ^ Murphy, R.; Decoursey, T. E. (2006). "Charge compensation during the phagocyte respiratory burst". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1757 (8): 996–1011. DOI:10.1016/j.bbabio.2006.01.005. PMID 16483534.
- ^ Capasso, M.; Bhamrah, M. K.; Henley, T.; Boyd, R. S.; Langlais, C.; Cain, K.; Dinsdale, D.; Pulford, K. et al. (2010). "HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species". Nature Immunology 11 (3): 265–272. DOI:10.1038/ni.1843. PMC 3030552. PMID 20139987. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3030552.
- ^ Capasso, M.; Decoursey, T. E.; Dyer, M. J. S. (2011). "PH regulation and beyond: Unanticipated functions for the voltage-gated proton channel, HVCN1". Trends in Cell Biology 21 (1): 20–28. DOI:10.1016/j.tcb.2010.09.006. PMC 3014425. PMID 20961760. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3014425.
- ^ Lee, S. Y.; Letts, J. A.; MacKinnon, R. (2009). "Functional Reconstitution of Purified Human Hv1 H+ Channels". Journal of Molecular Biology 387 (5): 1055–1060. DOI:10.1016/j.jmb.2009.02.034. PMC 2778278. PMID 19233200. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2778278.
- ^ Wood, M. L.; Schow, E. V.; Freites, J. A.; White, S. H.; Tombola, F.; Tobias, D. J. (2011). "Water wires in atomistic models of the Hv1 proton channel". Biochimica et Biophysica Acta (BBA) - Biomembranes. DOI:10.1016/j.bbamem.2011.07.045. PMID 21843503.
- ^ Ramsey, I. S.; Mokrab, Y.; Carvacho, I.; Sands, Z. A.; Sansom, M. S. P.; Clapham, D. E. (2010). "An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1". Nature Structural & Molecular Biology 17 (7): 869–875. DOI:10.1038/nsmb.1826. PMID 20543828.
- ^ Gonzalez, C.; Koch, H. P.; Drum, B. M.; Larsson, H. P. (2009). "Strong cooperativity between subunits in voltage-gated proton channels". Nature Structural & Molecular Biology 17 (1): 51–56. DOI:10.1038/nsmb.1739. PMC 2935852. PMID 20023639. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2935852.
- ^ Tombola, F.; Ulbrich, M. H.; Kohout, S. C.; Isacoff, E. Y. (2009). "The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity". Nature Structural & Molecular Biology 17 (1): 44–50. DOI:10.1038/nsmb.1738. PMC 2925041. PMID 20023640. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2925041.
- ^ Decoursey, T. E. (2008). "Voltage-gated proton channels: What's next?". The Journal of Physiology 586 (22): 5305–5324. DOI:10.1113/jphysiol.2008.161703. PMC 2655391. PMID 18801839. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2655391.
Further reading [link]
- Li SJ, Zhao Q, Zhou Q, et al. (2010). "The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1.". J. Biol. Chem. 285 (16): 12047–54. DOI:10.1074/jbc.M109.040360. PMID 20147290.
- Musset B, Smith SM, Rajan S, et al. (2010). "Oligomerization of the voltage-gated proton channel.". Channels (Austin) 4 (4): 260–5. PMC 3025757. PMID 20676047. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3025757.
- Lishko PV, Botchkina IL, Fedorenko A, Kirichok Y (2010). "Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel.". Cell 140 (3): 327–37. DOI:10.1016/j.cell.2009.12.053. PMID 20144758.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Musset B, Capasso M, Cherny VV, et al. (2010). "Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes.". J. Biol. Chem. 285 (8): 5117–21. DOI:10.1074/jbc.C109.082727. PMID 20037153.
- Petheo GL, Orient A, Baráth M, et al. (2010). "Molecular and functional characterization of Hv1 proton channel in human granulocytes.". PLoS ONE 5 (11): e14081. DOI:10.1371/journal.pone.0014081. PMID 21124855.
- Sasaki M, Takagi M, Okamura Y (2006). "A voltage sensor-domain protein is a voltage-gated proton channel.". Science 312 (5773): 589–92. DOI:10.1126/science.1122352. PMID 16556803.
- Lee SY, Letts JA, Mackinnon R (2008). "Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1.". Proc. Natl. Acad. Sci. U.S.A. 105 (22): 7692–5. DOI:10.1073/pnas.0803277105. PMID 18509058.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
- Li SJ, Zhao Q, Zhou Q, Zhai Y (2009). "Expression, purification, crystallization and preliminary crystallographic study of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (Pt 3): 279–81. DOI:10.1107/S1744309109003777. PMID 19255483.
- Suenaga T, Arase H, Yamasaki S, et al. (2007). "Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function.". Eur. J. Immunol. 37 (11): 3197–207. DOI:10.1002/eji.200737052. PMID 17948262.
- Iovannisci D, Illek B, Fischer H (2010). "Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T.". J. Gen. Physiol. 136 (1): 35–46. DOI:10.1085/jgp.200910379. PMID 20548053.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. DOI:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Musset B, Cherny VV, Morgan D, et al. (2008). "Detailed comparison of expressed and native voltage-gated proton channel currents.". J. Physiol. (Lond.) 586 (10): 2477–86. DOI:10.1113/jphysiol.2007.149427. PMID 18356202.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ramsey IS, Moran MM, Chong JA, Clapham DE (2006). "A voltage-gated proton-selective channel lacking the pore domain.". Nature 440 (7088): 1213–6. DOI:10.1038/nature04700. PMID 16554753.
- Sakata S, Kurokawa T, Nørholm MH, et al. (2010). "Functionality of the voltage-gated proton channel truncated in S4.". Proc. Natl. Acad. Sci. U.S.A. 107 (5): 2313–8. DOI:10.1073/pnas.0911868107. PMID 20018719.
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