HSD
HSD may refer to:
School districts
Other uses
11-Beta hydroxysteroid dehydrogenase
11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) is the name of a family of enzymes that catalyze the conversion of inert 11 keto-products (cortisone) to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors:
Thus, the two substrates of this enzyme are 11beta-hydroxysteroid and NADP+, whereas its 3 products are 11-oxosteroid, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 11beta-hydroxysteroid:NADP+ 11-oxidoreductase. Other names in common use include corticosteroid 11β-dehydrogenase, β-hydroxysteroid dehydrogenase, 11β-hydroxy steroid dehydrogenase, corticosteroid 11-reductase, and dehydrogenase, 11β-hydroxy steroid. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1XSE, 1XU7, 1XU9, 1Y5M, 1Y5R, 2BEL, 2ILT, and 2IRW.
11β-hydroxysteroid dehydrogenase type 1
11β-hydroxysteroid dehydrogenase type 1, or 'cortisone reductase' is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.
Function
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Clinical significance
11β-HSD1 is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Moreover, 18alpha-glycyrrhizic acid from the root of glycyrrhiza glabra was discovered as an inhibitor.
Podcasts:
HSD
ALBUMS
- DJ Maddix Presents 'Rumble in the Jungle 2010' released: 2010
DJ Maddix Presents 'Rumble in the Jungle 2010'
Released 2010- Bloody Fives
- Beyond the Rise
- Someone Like You
- The Great Risk
- Vegas (Johnny Hooves remix)
- Its a Free World
- Is This Really Real
- Morning Glory (Trisector remix)
- Timeslip
- Sleepless (feat. Teknik)
- Darktimes (State of Mind Remix)
- Creepout
- Quench
- Wrecked (Imprintz & Kloe remix) (feat. Analog MC)
- Brain Drain
- Vision (Agent Alvin remix)
- Submission
- Relaxing Smoke of Crack
- The Scientist (feat. Lightness)
- Mirage
- To Need
- You Tell Me
- Whispered
- AMC
hsd
ALBUMS
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Love Is Like Oxygen
by: SweetLove is like oxygen
You get too much you get too high
Not enough and you're gonna die
Love gets you high
Love is like oxygen
. . .
Time on my side
I got it all
I've heard that pride
Always comes before a fall
There's a rumour goin' round the town
That you don't want me around
I can't shake off my city blues
Every way I turn I lose
Love is like oxygen
. . .
Love is like oxygen
. . .
Time is no healer
If you're not there
Lonely fever
Sad words in the air
Some things are better left unsaid
I'm gonna spend my days in bed
I'll walk the streets at night
To be hidden by the city lights
City lights
Love is like oxygen
. . .
Love is like oxygen
Latest News for: hsd
HSD Employee Spotlight—Temesgen Melashu (City of Seattle, WA)
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