Ness may refer to:
The surname Ness may refer to:
EarthBound, known as Mother 2 in Japan, is a 1994 Japanese role-playing video game co-developed by Ape Inc. and HAL Laboratory and published by Nintendo for the Super Nintendo Entertainment System video game console. As Ness and his party of four, the player travels the world to collect melodies en route to defeating the evil alien force Giygas. It is the second game of the Mother series, and the only one to be released in the English language until its predecessor was released under the name EarthBound Beginnings in 2015 as part of Wii U's Virtual Console.EarthBound was released in Japan on August 27, 1994, and in North America on June 5, 1995.
The game had a lengthy development period which spanned five years. Its making involved a number of Japanese luminaries, including writer Shigesato Itoi, musician/songwriter Keiichi Suzuki, sound designer Hirokazu Tanaka, and future Nintendo president Satoru Iwata. Themed around an idiosyncratic portrayal of Americana and Western culture, it subverted popular role-playing game traditions by featuring a real world setting while parodying numerous staples of the genre. Itoi, who directed the game, wanted it to reach non-gamers with its intentionally goofy tone. It was heavily marketed upon release via a promotional campaign which sardonically proclaimed "this game stinks".
Hox genes (also known as homeotic genes) are a group of related genes that control the body plan of an embryo along the cranio-caudal (head-tail) axis. After the embryonic segments have formed, the Hox proteins determine the type of segment structures (e.g. legs, antennae, and wings in fruit flies or the different types of vertebrae in humans) that will form on a given segment. Hox proteins thus confer segmental identity, but do not form the actual segments themselves.
Hox genes are defined as having the following properties:
The products of Hox genes are Hox proteins. Hox proteins are transcription factors, which are proteins that are capable of binding to specific nucleotide sequences on the DNA called enhancers where they either activate or repress genes. The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox). This amino acid sequence folds into a "helix-turn-helix" (i.e. homeodomain fold) motif that is stabilized by a third helix. The consensus polypeptide chain is (typical intron position noted with dashes):