Nuclear receptor coactivator 3

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.

Interactions

Nuclear receptor coactivator 3 has been shown to interact with:

Home directory

A home directory is a file system directory on a multi-user operating system containing files for a given user of the system. The specifics of the home directory (such as its name and location) is defined by the operating system involved; for example, Windows systems between 2000 and 2003 keep home directories in a folder called Documents and Settings.

Description

A user's home directory is intended to contain that user's files; including text documents, music, pictures or videos, etc. It may also include their configuration files of preferred settings for any software they have used there and might have tailored to their liking: web browser bookmarks, favorite desktop wallpaper and themes, passwords to any external services accessed via a given software, etc. The user can install executable software in this directory, but it will only be available to users with permission to this directory. The home directory can be organized further with the use of sub-directories.

The content of a user's home directory is protected by file system permissions, and by default is accessible to all authenticated users and administrators. Any other user that has been granted administrator privileges has authority to access any protected location on the filesystem including other users home directories.

Home (Deep Blue Something album)

Home is the second album by alternative rock band Deep Blue Something. It was originally released by RainMaker Records in 1994 and re-released on Interscope in 1995.

Track listing

All songs written by Todd Pipes, except where noted.

B-Sides:

Charts

Personnel

Band Members

Home (Stephanie Mills album)

Home is a studio album by Stephanie Mills. It was released June 26, 1989 on MCA Records.

Track listing

Charts

References

External links