List of Hollows in Bleach

In the fictional Bleach manga/ anime universe, a hollow (虚(ホロウ, horō) is a monstrous ghost that ought to be slain and purified or else it will feed on other souls. Many of the series' antagonists are hollows; also, the fictional universe also has hollows with Soul Reaper(a death-related entity)-like characteristics called arrancars (破面(アランカル), arankaru, Spanish for "to tear off," kanji translates as "broken mask"). One of the series' main storylines has Sōsuke Aizen (the primary antagonist for the majority of the series) and his arrancars (particularly the ten Espadas, the strongest ones) as the force opposing the protagonists.

The creator of the series, Tite Kubo, used many Spanish motifs for the series' hollow-related elements. The fictional creatures have been praised by reviewers for the early hollows' strong emotional ties to their victims and the "interesting" concept of the arrancar; the visual appearance of the characters have also been commented on.

In-universe Overview of Hollows

Hollow (Digital Summer album)

Hollow is an EP/DVD release from hard rock five piece Digital Summer. It was released on March 31, 2008, and featured the single "Rescue Me".

Track listing

Disc 1

Disc 2

Miscellaneous information

Personnel

Valley

A valley is a low area between hills, often with a river running through it.

In geology, a valley or dale is a depression that is longer than it is wide. The terms U-shaped and V-shaped are descriptive terms of geography to characterize the form of valleys. Most valleys belong to one of these two main types or a mixture of them, (at least) with respect to the cross section of the slopes or hillsides.

Valley terminology

A valley in its broadest geographic sense is also known as a dale. A valley through which a river runs may also be referred to as a vale. A small, secluded, and often wooded valley is known as a dell or in Scotland as a glen. A wide, flat valley through which a river runs is known in Scotland as a strath. A mountain cove is a small valley, closed at one or both ends, in the central or southern Appalachian Mountains which sometimes results from the erosion of a geologic window. A small valley surrounded by mountains or ridges is sometimes known as a hollow. A deep, narrow valley is known as a cwm (also spelled combe or coombe). Similar geological structures, such as canyons, ravines, gorges, gullies, and kloofs, are not usually referred to as valleys. See also: "chine". A valley formed by erosion is called an erosional valley; a valley formed by geologic events such as drop faults or the rise of highlands is called a structural valley.

Mdm2

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation.

Discovery and expression in tumor cells

The murine double minute (mdm2) oncogene, which codes for the Mdm2 protein, was originally cloned, along with two other genes (mdm1 and mdm3) from the transformed mouse cell line 3T3-DM. Mdm2 overexpression, in cooperation with oncogenic Ras, promotes transformation of primary rodent fibroblasts, and mdm2 expression led to tumor formation in nude mice. The human homologue of this protein was later identified and is sometimes called Hdm2. Further supporting the role of mdm2 as an oncogene, several human tumor types have been shown to have increased levels of Mdm2, including soft tissue sarcomas and osteosarcomas as well as breast tumors. The MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. MDM2 supports the Polycomb-mediated repression of lineage-specific genes, independent of p53. MDM2 depletion in the absence of p53 promoted the differentiation of human mesenchymal stem cells and diminished clonogenic survival of cancer cells. Most of the MDM2-controlled genes also responded to the inactivation of the Polycomb Repressor Complex 2 (PRC2) and its catalytic component EZH2. MDM2 physically associated with EZH2 on chromatin, enhancing the trimethylation of histone 3 at lysine 27 and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes. Removing MDM2 simultaneously with the H2AK119 E3 ligase Ring1B/RNF2 further induced these genes and synthetically arrested cell proliferation.