HMB-45

HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for human melanoma black 45. It is used in anatomic pathology as a marker for such tumors. The specific antigen recognized by HMB-45 is now known as Pmel 17.

HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. The antibody was generated to an extract of melanoma. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity.

In a study to determine diagnostic usefulness of specific antibodies used to identify melanoma, HMB-45 had a 92% sensitivity when used to identify melanoma. The antibody also reacts positively against junctional nevus cells and fetal melanocytes.

Despite this relatively high sensitivity—HMB-45 does have its drawbacks. HMB-45 can be detected in only 50-70% of melanomas. HMB-45 does not react well against intradermal nevi, normal adult melanocytes, spindle cell melanomas and desmoplastic melanomas. HMB-45 is nonreactive with almost all non-melanoma human malignancies, with the exception of rare tumors showing evidence of melanogenesis (e.g., pigmented schwannoma, clear cell sarcoma) or tumors associated with tuberous sclerosis complex (angiomyolipoma and lymphangiomyoma).

HMB

HMB may refer to:

Hughes Mining Barge

The Hughes Mining Barge, or HMB-1, is a submersible barge about 99 m (324 ft) long, 32 m (106 ft) wide, and more than 27 m (90 ft) tall. The HMB-1 was originally developed as part of Project Azorian (more widely, but erroneously, known as "Project Jennifer"), the top-secret effort mounted by the Central Intelligence Agency to salvage the remains of the Soviet submarine K-129 from the ocean floor.

The HMB-1 was designed to allow the device that would be used to grasp and lift the submarine to be constructed inside the barge and out of sight, and to be installed in the Glomar Explorer in secrecy. This was done by towing the HMB-1, with the capture device inside, to a location near Catalina Island (off the coast of California), and then submerging it onto stabilizing piers that had been installed on the seafloor. The Glomar Explorer was then maneuvered over the HMB-1, the retractable roof was opened, and the capture device lifted into the massive "moon pool" of the ship, all within clear sight of people on the beach.