HLA-DR4

HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

Serology

The serological identification of DR4 is good. The serology of DRB1*04:17 to *04:60 is unknown.

Disease associations

By serotype

DR4 is associated with extraarticularrheumatoid arthritis, hydralazine-induced female systemic lupus erythematosus, pemphigoid gestationis,pemphigus foliaceus, obstructive hypertrophic cardiomyopathy, IgA nephropathy, 'shared syndrome'-systemic sclerosis/rheumatoid arthritis and polymyalgia rheumatica.

By allele

DRB1*04 is associated with increased risk for alopecia areata.

DRB1*04:01 is associated with multiple sclerosis, rheumatoid arthritis, type 1 diabetes, lyme disease induced arthritis

DRB1*04:02: drug-triggered/idiopathic pemphigus vulgaris, type 1 diabetes, SLE associated anti-cardiolipin and anti-β₂ glycoprotein I

DRB1*04:03: polycystic ovary syndrome, SLE associated anti-cardiolipin and anti-β₂ glycoprotein I

HLA

HLA may refer to:

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HLA (radio station)

Coordinates: 36°23′15″N 127°21′59″E / 36.38753°N 127.36650°E / 36.38753; 127.36650 (HLA time signal antenna) HLA is a time signal radio station in Daejeon, South Korea, operated by the Korea Research Institute of Standards and Science. Established on November 24, 1984, it transmits a 2 kW signal on 5 MHz (±0.01 Hz). Originally only transmitted for 7 hours per day (01:00–08:00), 5 days per week (M–F), it is continuous as of 2011, There are over 100 users of the signal in Korea.

It broadcasts a time signal similar to that of the WWV and WWVH stations with which it shares a frequency:

References

External links