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| major histocompatibility complex, class II, DM alpha | |
|---|---|
 |
|
| Crystallographic structure of human HLA-DM.[1] | |
| Identifiers | |
| Symbol | HLA-DMA |
| Entrez | 3108 |
| HUGO | 4934 |
| OMIM | 142855 |
| RefSeq | NM_006120 |
| UniProt | P28067 |
| Other data | |
| Locus | Chr. 6 p21.3 |
| major histocompatibility complex, class II, DM beta | |
|---|---|
| Identifiers | |
| Symbol | HLA-DMB |
| Entrez | 3109 |
| HUGO | 4935 |
| OMIM | 142856 |
| RefSeq | NM_002118 |
| UniProt | P28068 |
| Other data | |
| Locus | Chr. 6 p21.3 |
HLA-DM is an intracellular protein involved in peptide presentation by MHC class II.[2] It is encoded by the genes HLA-DMA and HLA-DMB.
In the endosomes, HLA-DM functions by promoting the dissociation of the CLIP peptide (a place holder peptide) from MHC class II which allows endosomal peptides to bind. Possibly by its preferential binding of the open, peptide-less conformation of MHC class II, HLA-DM then catalyzes peptide exchange, favoring more stable peptide-MHC complexes (which are resistant to DM action). Thus, HLA-DM is thought to play an important role in "editing" the peptide repertoire.
HLA-DM is a protein involved in the immune system. It is a molecular chaperone that works in lysosomes and endosomes. HLA-DM plays a role in the proper loading of peptides and presentation of the peptides in macrophages, dendritic cells, B cells, and other antigen presenting cells. The protein is unable to bind peptides itself, so it interacts with major histocompatibility protein II (MHCII) to speed up the molecule’s binding and releasing of peptides. HLA-DM regulates the peptides that bind to MHCII and present the antigen on antigen presenting cells, therefore controlling which antigen(s) the body mounts and immune response to.
The genes for HLA-DM are located in the MHCII region of the human chromosome 6. The genes code for the alpha and beta chains that makeup the protein. HLA-DM consists of two polymers and three ligands: BETA-D-MANNOSE (BMA), CHLORIDE ION (CL), and 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE (NDG). The structure of HLA-DM was determined by x-ray diffraction at a resolution of 2.27 Å.
The Ramachandran Plot of HLA-DM can be seen here here.
References [link]
- ^ PDB 2BC4; Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW (April 2006). "Small molecules that enhance the catalytic efficiency of HLA-DM". J. Immunol. 176 (7): 4208–20. PMID 16547258.
- ^ Busch R, Rinderknecht CH, Roh S, Lee AW, Harding JJ, Burster T, Hornell TM, Mellins ED (October 2005). "Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression". Immunol. Rev. 207: 242–60. DOI:10.1111/j.0105-2896.2005.00306.x. PMID 16181341.
3. Vogt Anne B, Kropshofer Harald (April 1999). "HLA-DM – an endosomal and lysosomal chaperone for the immune system". Trends in Biochemical Sciences. 24 (4): 150-154. doi:10.1016/S0968-0004(99)01364-X
External links [link]
- Overview at Davidson College (student generated)
- [1] Protein Data Bank
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https://wn.com/HLA-DM
HLA
HLA may refer to:
Biochemistry
Computing
Engineering
People
Politics
HLA (radio station)
Coordinates: 36°23′15″N 127°21′59″E / 36.38753°N 127.36650°E HLA is a time signal radio station in Daejeon, South Korea, operated by the Korea Research Institute of Standards and Science. Established on November 24, 1984, it transmits a 2 kW signal on 5 MHz (±0.01 Hz). Originally only transmitted for 7 hours per day (01:00–08:00), 5 days per week (M–F), it is continuous as of 2011, There are over 100 users of the signal in Korea.
It broadcasts a time signal similar to that of the WWV and WWVH stations with which it shares a frequency:
References
External links
Podcasts:
-
by Lady May
Round Up
by: Lady May(woahh)
Yee-Haw!
What the hell is a yee-haw? (Well...)
That's that country shit
Yeah, May, Blu, (wheww) crazy cat, yeah.
Bob Marley (whewww)
That's that country shit...
Round up, round up, yeah
You know what we came to do
Dance floor bootylicious
Party with May and Blu
Hot tamales we bum rush the parties
In Danalies (?) on Ducalies (?) in drop-top Ferrari's
Fingernails, toenails, hair and makeup
Studded up my ear with a pair from Jacob's
New faced, dudes chase, mommie lookin' too laced
Honey's iced feelin' like they killin' with screw face
Me and my crew stay loose off that gray ?
Order bottles of ? with cranberry and grapefruit
Wet the sex kitten (grrr)
Start chillin' with stars
And fuck the bars
Puffin' cigars
12 in the afternoon
Runnin' kinda late I can't wait for you
Gotta have my hair done and my nail done, too
Just like every other girl plans to do. (dontcha, dontcha, dontcha know)
If you wanna ride it's ok
Keep in mind that I don't have all day
Gotta hurry up before the night slips away
Dontcha, dontcha, dontcha know ..
Round everybody up
Hit the club and tear it down
If you're up against the wall then you're in the wrong place
Game players not allowed
Everybody up in the crowd (dontcha, dontcha, dontcha know)
Don't hesitate come follow me now
Let me hear you all say
(wha, wha, wha, wha, what, what, what)
Oh, oh, oh, oh ,oh round up, round up
Let me hear you all say
Ooh, oh, oh, oh, oh
Dontcha,dontcha, dontcha know
You see my clique
We be in the party like it's our shit
Can't nobody tell us that we not it
VIP tables, minks and stables, rings in navels.
You know we got that long cash.
Smellin' like money when I walk past
You know I'm in a hurry; talk fast.
Pimps and players, players and pimps
Diamonds and links, buyin' me drinks
Boy you think ..
You know my sheezy pimpin' ain't easy
You know how many cats wanna get with May wheezy
The most glamorous, I'm not your average
So if I holla, holla back youngin' like Fabolous.
We can put our makeup on in the car
So we can dip on this journey of ours
Call my homies just to see where they are
And know that rollin' out (dontcha, dontcha, dontcha know)
you know so
Round everybody up
Hit the club and tear it down
If you're up against the wall then you're in the wrong place
Game players not allowed
Everybody up in the crowd (dontcha, dontcha, dontcha know)
don't hesitate come follow me now
Let me hear you all say
(wha, wha, wha, wha, what, what, what)
Oh, oh, oh, oh, oh round up, round up (yeah yeah yeah yeah)
Let me hear you all say
Ooh, oh, oh, oh, oh
Dontcha, dontcha, dontcha know
HEY YOU!!!!!!!!!!
Whatchu standin' on the wall for?
Know you wanna get on the floor stop actin' hard-core.
Standup, yeah
Keep them hands
Get it crunk up in the club like 'uh huh, uh huh, uh-huh'
That's why they boys, they boys they love me, love me
I meet 'em, greet 'em, tease 'em, May wheeze 'em
I got them beggin' for that "oochie wally, wally"
Ooh, she's a hottie, hottie
Dontcha, dontcha, dontcha know
5'6 frame, off the chain
Get in the fast lane
came to switch up the game (switchin' the game)
Dirty South to NY we be doin' our thing, baby
Goodbye for now (don't you know?)
Till we see you again
Round everybody up
Hit the club and tear it down
If you're up against the wall then you're in the wrong place
Game players not allowed
Everybody up in the crowd don't hesitate come follow me now
Let me hear you all say
(wha, wha, wha, wha, what, what, what)
Oh, oh, oh, oh ,oh round up, round up
Let me hear you all say
Ooh, oh, oh, oh, oh
Dontcha, dontcha, dontcha know
Round everybody up
Hit the club and tear it down
If you're up against the wall then you're in the wrong place
Game players not allowed
Everybody up in the crowd
don't hesitate come follow me now (yeahhh) (dontcha, dontcha, dontcha know)
Let me hear you all say
(wha, wha, wha, wha, what, what, what)
Oh, oh, oh, oh ,oh round up, round up
Let me hear you all say
Ooh, oh, oh, oh, oh
Dontcha, dontcha, dontcha know
Yee-Haw!