HLA-B58
HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B*58 gene products. (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.
Serotype
Allele distribution
Disease
HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome. Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN). The association with allopurinol sensitivity in JSJ/TEN was extremely strong in Asia, and somewhat less associated in Europeans.
References
HLA
HLA may refer to:
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HLA (radio station)
Coordinates: 36°23′15″N 127°21′59″E / 36.38753°N 127.36650°E / 36.38753; 127.36650 (HLA time signal antenna) HLA is a time signal radio station in Daejeon, South Korea, operated by the Korea Research Institute of Standards and Science. Established on November 24, 1984, it transmits a 2 kW signal on 5 MHz (±0.01 Hz). Originally only transmitted for 7 hours per day (01:00–08:00), 5 days per week (M–F), it is continuous as of 2011, There are over 100 users of the signal in Korea.
It broadcasts a time signal similar to that of the WWV and WWVH stations with which it shares a frequency:
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External links
Podcasts:
