HLA-A68

HLA-A68 (A68) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁸ subset of HLA-A α-chains. For A68, the alpha "A" chain are encoded by the HLA-A*68 allele group and the β-chain are encoded by B2M locus. A68 and A*68 are almost synonymous in meaning. A68 is a split antigen of the broad antigen serotype A28. A68 is a sister serotype of A69.

A68 is more common in North America.

Serotype

A68 is poor, with low specific detection, high non-specific identification by A28.

Disease Associations

By allele

A*68 is associated with higher viral load in HIV. A68 may be protective against symptomatic heart disease in Chaga's cardiomyopathy.

Allele freqeuncies

A68 can be subdivided into 3 alleles, *6801, *6802, *6803. *6801 can also be subdivided into *680101 and *680102 (previously called *68011 and *68012).

A*6801

A*6801 is higher in certain Native American groups, South Asian peoples, African peoples, however *6801 is at low levels in most of SE Asia, particularly the indigeonous populations. This is also reflected by low levels along the West Pacific Rim including Japan. The hiatus of *6801 breaks in Northern Japan with the 3% frequency found in the Ainu, which continues to increase with Arctic peoples and falls of in Native Americans. Whereas in the Western Eurasia's northern regions, A*6801 falls off. In both Africa and the New World both A*680101 and A*680102 can be found. Although in the New World A*680102 is more prevalent.

A68

A68 or A-68 may refer to:

Modern Benoni

The Modern Benoni is a chess opening that begins with the moves 1.d4 Nf6 2.c4 c5 3.d5 e6. It is classified under the ECO codes A60–A79. After the initial moves, Black proceeds to capture on d5, creating a majority of black pawns on the queenside. To support their advance, the king's bishop is usually fianchettoed on g7. These two features differentiate Black's setup from the other Benoni defences and the King's Indian Defence, although transpositions between these openings are common.

Frank Marshall invented the Modern Benoni in 1927, but his experiments with the opening went largely ignored for over 20 years. In the 1950s the system was revitalized by players in the Soviet Union, chief among them Mikhail Tal. Its subsequent adoption by players of a similarly aggressive and uncompromising style such as Bobby Fischer and Garry Kasparov established the opening's reputation as one of Black's most dynamic responses to 1.d4.

The Modern Benoni suffered a serious theoretical crisis in the 1980s and 1990s, when players as Black encountered great difficulties in meeting the Taimanov Attack and the Modern Main Line. Only in the 21st century has the opening's reputation and theoretical standing made a recovery. Notably, it was Vladimir Kramnik's choice when he needed a win with Black in the penultimate game of the 2004 World Championship.

HLA

HLA may refer to:

Biochemistry

Computing

Engineering

People

Politics

HLA (radio station)

Coordinates: 36°23′15″N 127°21′59″E / 36.38753°N 127.36650°E / 36.38753; 127.36650 (HLA time signal antenna) HLA is a time signal radio station in Daejeon, South Korea, operated by the Korea Research Institute of Standards and Science. Established on November 24, 1984, it transmits a 2 kW signal on 5 MHz (±0.01 Hz). Originally only transmitted for 7 hours per day (01:00–08:00), 5 days per week (M–F), it is continuous as of 2011, There are over 100 users of the signal in Korea.

It broadcasts a time signal similar to that of the WWV and WWVH stations with which it shares a frequency:

References

External links