Subtypes of HIV

One of the obstacles to treatment of the human immunodeficiency virus is its high genetic variability. HIV can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in the endangered west African primate sooty mangabey. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Some of the subtypes are known to be more virulent or are resistant to different medications. Likewise, HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses, although HIV-2 is known to cause AIDS.

Major types

HIV-1

HIV-1 is the most common and pathogenic strain of the virus. Scientists divide HIV-1 into a major group (Group M) and two or more minor groups, namely Group N, O and possibly a group P. Each group is believed to represent an independent transmission of SIV into humans (but subtypes within a group are not). A total of 39 ORFs are found in all six possible reading frames (RFs) of HIV-1 complete genome sequence, but only a few of them are functional.

.hiv

.hiv is a generic top-level domain (gTLD) proposed by the Berlin-based nonprofit dotHIV and owned by Uniregistry as of September 2014. It is the first open charitable gTLD and its ICANN designation states that the domain's operator is precluded from making a profit. Funds raised from .hiv domain sales will initially benefit projects to increase access to HIV/AIDS treatment in Rwanda, South Africa, Turkey, and the United States.

History

The top-level domain (TLD) was inspired by the anti-HIV/AIDS campaign by thjnk, a German advertising agency. thjnk's co-owner Michael Trautmann established dotHIV gemeinnütziger e.V. as a nonprofit and applied for the .hiv TLD. Despite the global relevance of HIV/AIDS, dotHIV was the only applicant for the .hiv TLD. The company signed a registration contract with ICANN in March 2014. Domains were made available for select companies and individuals during the July "sunrise" period, becoming generally available in August 2014. hiv became the first open charitable TLD and, according to one press release, "opens up a dedicated namespace that brings website owners together behind one goal: The end of AIDS".

HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.

HIV infects vital cells in the human immune system such as helper T cells (specifically CD4⁺ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4⁺ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells,apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4⁺ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4⁺ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

Hiv, Iran

Hiv (Persian: هيو‎‎, also Romanized as Hīv) is a village in Hiv Rural District, in the Central District of Savojbolagh County, Alborz Province, Iran. At the 2006 census, its population was 8,061, in 2,247 families.

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