| Deleted in bladder cancer 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | DBC1; DBCCR1; FAM5A | ||||||||||||
| External IDs | OMIM: 602865 MGI: 1928478 HomoloGene: 8754 GeneCards: DBC1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1620 | 56710 | |||||||||||
| Ensembl | ENSG00000078725 | ENSMUSG00000028351 | |||||||||||
| UniProt | O60477 | Q920P3 | |||||||||||
| RefSeq (mRNA) | NM_014618.2 | NM_019967.2 | |||||||||||
| RefSeq (protein) | NP_055433.2 | NP_064351.2 | |||||||||||
| Location (UCSC) | Chr 9: 121.92 – 122.13 Mb |
Chr 4: 68.42 – 68.62 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[1][2][3][1][2]
This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[3]
The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor supressor gene.
References [link]
- ^ a b Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet 6 (6): 913–9. DOI:10.1093/hmg/6.6.913. PMID 9175739.
- ^ a b Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics 59 (3): 335–8. DOI:10.1006/geno.1999.5891. PMID 10444335.
- ^ a b "Entrez Gene: DBC1 deleted in bladder cancer 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620.
Further reading [link]
- Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.
- Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33.". Genomics 48 (3): 277–88. DOI:10.1006/geno.1997.5165. PMID 9545632.
- Nishiyama H, Takahashi T, Kakehi Y, et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer.". Genes Chromosomes Cancer 26 (2): 171–5. DOI:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456.
- Nishiyama H, Gill JH, Pitt E, et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1.". Oncogene 20 (23): 2956–64. DOI:10.1038/sj.onc.1204432. PMID 11420708.
- Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors.". J. Urol. 168 (6): 2645–9. DOI:10.1097/01.ju.0000037848.19383.88. PMID 12442002.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells.". Oncogene 23 (1): 82–90. DOI:10.1038/sj.onc.1206642. PMID 14712213.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Beetz C, Brodoehl S, Patt S, et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma.". Oncol. Rep. 13 (2): 335–40. PMID 15643521.
- Izumi H, Inoue J, Yokoi S, et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.". Hum. Mol. Genet. 14 (8): 997–1007. DOI:10.1093/hmg/ddi092. PMID 15746151.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- Louhelainen JP, Hurst CD, Pitt E, et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.". Oncogene 25 (16): 2409–19. DOI:10.1038/sj.onc.1209228. PMID 16369496.
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Hit!
Hit! is a 1973 action film directed by Sidney J. Furie and starring Billy Dee Williams and Richard Pryor. It is about a federal agent trying to destroy a drug zone after his daughter dies from a heroin overdose.
An alternate title for the film was Goodbye Marseilles.
Note
Many of the people, both cast and crew, involved in this film had previously worked on Lady Sings the Blues (1972).
The role of Nick Allen was originally written for Steve McQueen.
See also
References
External links
Hit
Hit is a verb meaning to strike someone or something.
Hit or HIT may also refer to:
Education
In business
Computing and the internet
Science and medicine
Places
- Hīt District, a district centered on the Iraqi town
Hitā
Hitā (Sanskrit: हिता) means 'causeway' or 'dike'. In the Upanishads this word is used to mean 'subtle connections' or 'canals of subtle energies', or particular 'nerves' or 'veins'. The journey to the heart is said to be through seventy-two thousand subtle channels called Hitā; they are the beneficent active veins (filled with different types of serums).
Dilemma of Balaki
Proud Balaki skilled in expounding, eloquent, went to Ajatsatru, the King of Benares, to impart superior wisdom to him which he knew only as the conditioned Brahman; he knew about the physical and physiological categories and therefore, the king soon realized that Balaki did not know about Brahman. Balaki was not aware of the fact that whatever he knew was the result of ignorance, that the results of ignorance, being finite things, are separated from him. Ajatsatru then tells Balaki Gargya that reality is to be found in the deep-sleep-consciousness. Pippalada, the sage of the Prashna Upanishad, holds that sleep is caused by the senses being absorbed in that highest 'sensorium' the mind, which is why in deep sleep man is not able to hear, not to see, nor to smell because the mind is then merged into an ocean of light.
