Haemophilia

Haemophilia (also spelled hemophilia) is a group of hereditary genetic disorders that impairs the body's ability to control blood clotting, which is used to stop bleeding when a blood vessel is broken. Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, present in about 1 in 5,000–10,000 male births.Haemophilia B (factor IX deficiency) occurs in around 1 in about 20,000–34,000 male births.

Like other recessive sex-linked, X chromosome disorders, haemophilia is more likely to occur in males than females. This is because females have two X chromosomes while males have only one, so the defective gene is guaranteed to manifest in any male who carries it. Because females have two X chromosomes and haemophilia is rare, the chance of a female having two defective copies of the gene is very remote, so females are almost exclusively asymptomatic carriers of the disorder. Female carriers can inherit the defective gene from either their mother or father, or it may be a new mutation. Although it is not impossible for a female to have haemophilia, it is unusual: daughters which are the product of both a male with haemophilia A or B and a female carrier will possess a 50% chance of having haemophilia, while the non-sex-linked haemophilia C due to coagulant factor XI deficiency, which can affect either sex, is more common in Jews of Ashkenazi (east European) descent but rare in other population groups.

Hemophiliac (album)

Hemophiliac is a limited edition album of improvised experimental music by John Zorn, Ikue Mori and Mike Patton. The album was released as a limited edition 2-CD set of 2,500 copies, personally autographed by Zorn, Patton and Mori, on Zorn's Tzadik label.

Reception

The Allmusic review by Dean McFarlane awarded the album 4 stars stating "what a pity this monstrous work was not made more widely available, as it contains some of the more ferocious performances of free improvisation that the members of this trio have put to record throughout their disparate and eclectic careers".

Track listing

All compositions by Mori, Patton & Zorn

Disc One

Disc Two

Hemophiliac (band)

Hemophiliac is an experimental musical act. This group is billed as improvisational music from the outer reaches of madness. Mike Patton does voice effects along with John Zorn on saxophone and Ikue Mori on laptop electronics.

Discography