Hemoglobin A2

Hemoglobin A2 (HbA₂) is a normal variant of hemoglobin A that consists of two alpha and two delta chains (α₂δ₂) and is found at low levels in normal human blood. Hemoglobin A2 may be increased in beta thalassemia or in people who are heterozygous for the beta thalassemia gene.

HbA2 exists in small amounts in all adult humans (1.5-3.1% of all hemoglobin molecules) and is increased in people with Sickle-cell disease. Its biological importance is not yet known.

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Hemoglobin A

Hemoglobin A (HbA), also known as adult hemoglobin or α₂β₂, is the most common human hemoglobin tetramer, comprising over 97% of the total red blood cell hemoglobin. It consists of two alpha chains and two beta chains.

See also