S-45A

S-45A was an American satellite, which was lost in a launch failure in 1961. The satellite was intended to operate in a highly elliptical orbit, from which it was to have provided data on the shape of the ionosphere, and on the Earth's magnetic field. It was part of the Explorer programme, and would have been designated Explorer 12 had it reached orbit. It was the second of two identical satellites to be launched; the first, S-45, had also been lost in a launch failure, earlier in the year.

S-45A was launched aboard a Juno II rocket, serial number AM-19G. It was the final flight of the Juno II. The launch took place from Launch Complex 26B at the Cape Canaveral Air Force Station at 19:48:05 UTC on 24 May 1961. The system which was intended to ignite the second stage malfunctioned, and as a result that stage failed to ignite. The rocket failed to achieve orbit.

References

S100A13

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

S100A13 has been shown to interact with SYT1 and FGF1.

Pathology

Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.

S100A11

S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene.

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.

Interactions

S100A11 has been shown to interact with Nucleolin and S100B.

References

Further reading

It's a Business

It's a Business was a television sitcom that aired on the DuMont Television Network for only 10 episodes.

Broadcast history

It's a Business aired on DuMont from March 19 to May 21, 1952, and was a half-hour program that aired on Wednesdays at 9 pm. The series starred Bob Haymes and Leo De Lyon as Broadway song publishers in the 1900s, during the vaudeville era, and Dorothy Loudon (making her television debut) as their secretary.

The program was directed by Frank Bunetta and written by Bob Weiskopf.

Episode status

As with most DuMont series, no episodes are known to survive.

See also

Bibliography

Business (EP)

Business is the debut EP from New Jersey, rock band Jet Lag Gemini,. Recorded in Madison, NJ at Northshore Studios when two of the band members were still 15 years old, the EP was released June 6, 2006 on Doghouse Records.

Track listing

References

Business (song)

"Business" is a song by American rapper Eminem from his fourth studio album The Eminem Show (2002). "Business" was released as the final single from The Eminem Show in July 2003. The single was not released in the United States.

Composition

"Business" is a hip hop song of four minutes and eleven seconds in length. It sees Eminem comparing himself and Dr. Dre, the song's producer, to fictional crime-fighting duo Batman and Robin, a comparison first explored in the music video for the previous Eminem single "Without Me". The lyrics are backed by a "cartoonish" beat: one of several Dr. Dre productions on The Eminem Show which, according to CultureDose writer Marty Brown, affords Eminem a "perfect sound-scape" to inspire emotions in the listener, calling the beat "a launchpad equally effective for humor or anger". Writing for Pitchfork Media, Ethan P. noted the "cartoonish" production to be similar in style to several of Eminem's early singles, claiming it to be fitting to the Batman and Robin theme on "Business", but noted that "this time he's actually talking about Batman and Robin!!". DX Magazine editor J-23 called this "classic" with Dre beats. Kris Ex On "Business": "Em names himself the gatekeeper of hip-hop and obliquely claims to be the best rapper alive: "The flow's too wet/Nobody close to it/Nobody says it, but everybody knows the shit."

Interstate 85 Business

Interstate 85 Business or Business Interstate 85 may refer to: