Heat rub

Heat rub is the name for a variety of products intended to relieve the pain of fibrositis, lumbago and muscular aches and strains. They are so named because they produce a feeling of warmth within the muscle of the area they are applied to, typically acting as rubefacients via a counterirritant effect.

Heat rubs are typically applied in cream form, but patches, sticks and sprays are also available.

Active ingredients are typically Menthol and Methyl Salicylate but could also include more exotic ingredients like cayenne.

The methyl salicylate that is the active analgesic ingredient in some heat-rub products can be toxic if they are used in excess.Heating pads are also not recommended for use with heat rubs, as the added warmth may cause overabsorption of the active ingredients.

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Date honey

Date honey, date syrup, or rub (Arabic: رُب, pronounced [rubb]) (Hebrew and Judeo-Iraqi Arabic: סילאן, pronounced [silan]) is a thick dark brown, very sweet fruit syrup extracted from dates. It is widely used in North African and Middle Eastern cooking.

It is used widely in Libya, usually with asida.

It is used in Israel, under the name silan, as a Dip for bread, in pastries, as a topping for malabi, to cook sweet chicken dish then rolled with a sesame or nuts which is served as a meze in southern and eastern parts of the country, it is also halik (similar to haroset) for Passover.

The honey in the Biblical reference of “a land flowing with milk and honey” (for example, Exod 3:8) is date honey.

Date syrup is rich in the monosacchirides glucose and fructose, and so most of its sugar content is absorbed into the bloodstream in the mouth, meaning that it raises the blood glucose levels more efficiently and immediately than other syrups. It is therefore highly suitable for people suffering from hypoglycaemia, or for those with sucrose intolerance or those with pancreatic problems who have difficulty absorbing disacchirides.

Rubí (1968 telenovela)

Rubí, is a Mexican telenovela produced by Televisa and originally transmitted by Telesistema Mexicano.

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NEDD8

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (In Saccharomyces cerevisiae this protein is known as Rub1.) This ubiquitin-like protein (ULP), which becomes covalently conjugated to a limited number of cellular proteins in a manner analogous to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The most substrates of NEDD8 modification are the Cullin subunits of Cullin-based E3 ubiquitin ligases, which are active only when neddylated. Their NEDDylation is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.

Activation and conjugation

As with ubiquitin and SUMO, NEDD8 is conjugated to cellular proteins after its C-terminal tail is processed. The NEDD8 activating E1 enzyme is a heterodimer composed of APPBP1 and UBA3 subunits. The APPBP1/UBA3 enzyme has homology to the N- and C-terminal halves of the ubiquitin E1 enzyme, respectively. The UBA3 subunit contains the catalytic center and activates NEDD8 in an ATP-dependent reaction by forming a high-energy thiolester intermediate. The activated NEDD8 is subsequently transferred to the UbcH12 E2 enzyme, and is then conjugated to specific substrates in the presence of the appropriate E3 ligases.

Minoru Tanaka (wrestler)

Minoru Tanaka (田中稔, Tanaka Minoru, born November 29, 1972 in Komaki, Aichi) is a Japanese professional wrestler and shootboxer. He is currently signed to Wrestle-1. Prior to W-1, Tanaka first gained prominence in Fujiwara Gumi and Battlarts before moving on to New Japan Pro Wrestling, where he became a four time IWGP Junior Heavyweight Champion, a five time IWGP Junior Heavyweight Tag Team Champion and the winner of the 2006 Best of the Super Juniors tournament. After leaving NJPW, he joined All Japan Pro Wrestling, where he found continued success in the junior heavyweight and tag team ranks upon winning the World Junior Hevyweight Championship once and the All Asia Tag Team Championship twice.

Professional wrestling career

Early years

Minoru Tanaka was originally a shootboxer. He started his career as a wrestler in Fujiwara Gumi, trained by its owner, Yoshiaki Fujiwara. In late 1995, Tanaka and everyone else in the promotion abandoned Fujiwara and formed their own promotion, Battlarts, led by Yuki Ishikawa. Despite being a simulated shoot style professional wrestling promotion, Battlarts, like its predecessor, often cooperated with other federations and styles, such as Fighting Network Rings, Kingdom, Michinoku Pro and Big Japan Pro Wrestling. Tanaka's first championship, the UWA World Middleweight Championship (originally based in Mexico and introduced in Japan through Universal Lucha Libre and Michinoku), came in 1996. He later won Frontier Martial Arts Wrestling's Independent World Junior Heavyweight Championship (which was outsourced to Battlarts after Hiromichi Fuyuki abolished all previous FMW titles and replaced them with WEW titles).

Heat (Lupica novel)

Heat is a young adult novel written by Mike Lupica that was published in 2006.

Book

The book is set in The Bronx, New York. The main character is a young boy named Michael Arroyo, a gifted baseball player. Coaches from other teams say that he is too good to be just 12 years old. With no parents, and a birth certificate back at his native home Cuba, Michael will have to somehow prove with the help of his best friend, Manny, and his brother Carlos that he really is the age that he says. Later on in the book, Michael also meets a girl named Ellie who is beautiful and mysterious.

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Wild Card (2015 film)

Wild Card is a 2015 American crime thriller film directed by Simon West, and starring Jason Statham, Michael Angarano, Dominik Garcia-Lorido, Milo Ventimiglia, Hope Davis, and Stanley Tucci. The film is based on the 1985 novel Heat by William Goldman, and is a remake of the 1986 adaptation that starred Burt Reynolds. The film was released in the United States on January 30, 2015 in a limited release and through video on demand.

Wild Card was a "box office bomb", making only $6.0 million against a $30 million budget.

Plot

Nick Wild (Jason Statham) is a recovering gambling addict who takes odd jobs in Las Vegas as a "chaperone" (his version of a bodyguard) to support his addiction. After helping a client impress a woman (Sofia Vergara), he accepts a proposition from meek self-made millionaire Cyrus Kinnick (Michael Angarano) to show him around Vegas and provide him with protection while he gambles.

While eating at a diner, Nick's waitress friend Roxy (Anne Heche) hands him a message from a woman he knows, Holly (Dominik Garcia-Lorido), who wants him to stop by her house. Holly, a professional escort, explains she had a date the previous night at the Golden Nugget. Afterward, she was brutally raped and beaten by three unknown men in their hotel room. Holly asks Nick to find out who they are so that she can sue them, though unbeknownst to Nick, she plans to take revenge.