HULC (gene)
In molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a long non-coding RNA. It was first identified in hepatocellular carcinoma, and is also expressed in colorectal carcinomas that metastasise to the liver. It may have a role in the post-transcriptional regulation of gene expression. It downregulates the expression of several microRNAs, including miR-372. Expression of HULC is upregulated by CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.
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Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.
Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.
Eugene (given name)
Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.
Male foreign-language variants include:
Notable people
Christianity
Military
Gene (novel)
Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.
Characters
Cyclades (born circa 1300 BC)
Incarnations of Cyclades
Athanatos (born circa 1500 BC)
Incarnations of Athanatos
Human Universal Load Carrier
Human Universal Load Carrier, or HULC, is an un-tethered, hydraulic-powered anthropomorphic exoskeleton developed by Professor H. Kazerooni and his team at Ekso Bionics. It is intended to help soldiers in combat carry a load of up to 200 pounds at a top speed of 10 miles per hour for extended periods of time. After being under development at Berkeley Robotics and Human Engineering Laboratory since 2000, the system was announced publicly at the AUSA Winter Symposium on February 26, 2009 when an exclusive licensing agreement was reached with Lockheed Martin.
Development
Lockheed Martin entered into an exclusive licensing agreement with Ekso Bionics (formerly Berkeley Bionics) in January 2009. The program is based in Orlando Florida at the Lockheed Martin Missiles & Fire Control business unit and the program manager is Jim Ni.
Lockheed Martin is currently developing a new, ruggedized HULC system which will be evaluated by the US Army Natick Soldier Research, Development and Engineering Center (NSRDEC). The upgraded HULC system includes optimized control software, extended battery life and human factors improvements for quicker and easier sizing to each user. Lockheed Martin is also exploring exoskeleton designs to support industrial and medical applications.
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