HU-336
Systematic (IUPAC) name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-1H-benzo[c]chromene-1,4(6H)-dione
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
ATC code  ?
PubChem CID 11370880
ChemSpider 9545797 YesY
Chemical data
Formula C21H28O3
Mol. mass 328.445
SMILES eMolecules & PubChem
 YesY (what is this?)  (verify)

HU-336 is a strongly antiangiogenic compound, significantly inhibiting angiogenesis at concentrations as low as 300nM. It inhibits angiogenesis by directly inducing apoptosis of vascular endothelial cells without changing the expression of pro- and antiangiogenic cytokines and their receptors. HU-336 is highly effective against tumor xenografts in nude mice.[1]

See also [link]

References [link]

  1. ^ Natalya M. Kogan, Cristina Blázquez, Luis Alvarez, Ruth Gallily, Michael Schlesinger, Manuel Guzmán, and Raphael Mechoulam (2006). "A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells". Molecular Pharmacology 70 (1): 51–59. PMID 16571653. 

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Podcasts:

PLAYLIST TIME:

High 5

by: Beck

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like a man from the Catskills! High 5! More dead than alive! Rocking
the plastic like a man from the
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get the other record! Damn!\"
High 5! More dead than alive! Rocking the plastic like a man from the
Catskills! High 5! More dead
than alive! Rocking the plastic like a man from the Catskills! High 5!
More dead than alive! Rocking the
plastic like a man from the Catskills! High 5! More dead than alive!
Rocking the plastic like a man from
the Catskills! [Mike D]: \"Ok, now. Do like designer jeans. Everybody,
designer jeans! say, say, say,
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Let me hear you say: Sergio Valente!




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