5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first given importance as a target of serotonergic psychedelic drugs such as LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.
5-HT2A may be a necessary receptor for the spread of the human polyoma virus called JC virus.
Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and classical antipsychotics. Deceased suicidal and otherwise depressed patients have had more 5-HT2A receptors than normal patients. These findings suggest that post-synaptic 5-HT2A overdensity is involved in the pathogenesis of depression.
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Day Job 1.0
by: TR-iDon't quit your day job
Corporate-crybaby
A bit wiser and a whole lot older, feelin' bolder
Suckin' up to the last stockholder with a
Golden parachute slung over your shoulder
Jacked-up-B-boy
Another fool got stuck in the whirlpool
Lookin' for a fast break, not enough cake to go 'round
Another brother goes down, and he's out of the gene pool
Media-pimp
Day after day, night after night if the money is right
The campaign goes on to make right seem wrong
With computer animation and a hip-hop song
Land of opportunity, this is the
Stop
Don't quit your day job
Cowboy-politician
Suckin' up to the aristocracy
Not even sure if you like democracy
Tryin' to establish an american royalty, a personal dynasty
Priests-of-the-airwaves
Let the buyer beware, it's a jungle out there
So buy my advice and don't think twice
Then me and your money will go someplace sunny
Celebrity-stud-monkey
Kiss and tell, got a book to sell
'Cause you don't excel or do anything well
Since you slipped past thirty, better keep the sex dirty
Mo' money, mo' money, mo' money