HSP90AB1

Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the HSP90AB1 gene.

Function

HSP90AB1 is a molecular chaperone. Chaperones are proteins that bind to other proteins, thereby stabilizing them in an ATP-dependent manner. Chaperones stabilize new proteins during translation, mature proteins which are partially unstable but also proteins that have become partially denatured due to various kinds of cellular stress. In case proper folding or refolding is impossible, HSPs mediate protein degradation. In addition, they have also specialized functions, such as intracellular transport into organelles.

Classification

Human HSPs are classified into 5 major groups according to the HNGC (HUGO gene nomenclature committee):

Chaperonins are characterized by their barrel-shaped structure with binding sites for client proteins inside the barrels.

Human HSP90 proteins are classified into 5 major groups according to the HNGC: