HSD17B1

Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene.

Human 17β-HSD1 was the first enzyme of the 17β-HSD family to be cloned and to have its sequence identified. Its three-dimensional structure is also the first example of any human steroid-converting enzyme.

This enzyme contains 327 amino acids and exists as a homodimer with two identical subunits of 34.5 kDa

17β-HSD1 expression positively correlates to estrone activation, E2 levels, and proliferation of breast cancer cells The multi-specificity of 17β-HSD1 is structurally based on the pseudo-symmetric structures of androgens that can accommodate the narrow enzyme substrate tunnel by both normal and alternative binding. Thus, 17β-HSD1 up-regulates breast cancer cell growth by a combined action on estradiol synthesis and dihydrotestosterone inactivation.

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