HRB

HRB may refer to:

HRB (gene)

Arf-GAP domain and FG repeats-containing protein 1 is a protein that in humans is encoded by the AGFG1 gene.

Function

The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Interactions

HRB (gene) has been shown to interact with EPS15L1 and EPS15.

References

Further reading

Boeing Vertol CH-46 Sea Knight

The Boeing Vertol CH-46 Sea Knight is a medium-lift tandem rotor transport helicopter powered by twin turboshaft aircraft engines. It was used by the United States Marine Corps (USMC) to provide all-weather, day-or-night assault transport of combat troops, supplies and equipment until it was replaced by the MV-22 Osprey. Additional tasks included combat support, search and rescue (SAR), support for forward refueling and rearming points, CASEVAC and Tactical Recovery of Aircraft and Personnel (TRAP).

The Sea Knight was also the U.S. Navy's standard medium-lift utility helicopter until it was phased out in favor of the MH-60S Knighthawk in the early 2000s. Canada also operated the Sea Knight, designated as CH-113, and operated them in the SAR role until 2004. Other export customers include Japan, Sweden, and Saudi Arabia. The commercial version is the BV 107-II, commonly referred to simply as the "Vertol".

Development

Origins

Piasecki Helicopter was a pioneering developer of tandem-rotor helicopters, with the most famous previous helicopter being the H-21 "Flying Banana". Piasecki Helicopter became Vertol in 1955 and work began on a new tandem rotor helicopter designated the Vertol Model 107 or V-107 in 1956. The V-107 prototype had two Lycoming T53 turboshaft engines, producing 877 shp (640 kW) each. The first flight of the V-107 took place on 22 April 1958. The V-107 was then put through a flight demonstration tour in the United States and overseas. In June 1958, the U.S. Army awarded a contract to Vertol for ten production aircraft designated "YHC-1A".