Haptoglobin-related protein
Identifiers
Symbols HPR; A-259H10.2; HP
External IDs OMIM140210 MGI96211 HomoloGene122206 GeneCards: HPR Gene
RNA expression pattern
PBB GE HPR 208471 at tn.png
PBB GE HPR 208470 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3250 15439
Ensembl ENSG00000261701 ENSMUSG00000031722
UniProt P00739 Q3UBS3
RefSeq (mRNA) NM_020995.3 NM_017370
RefSeq (protein) NP_066275.3 NP_059066
Location (UCSC) Chr 16:
72.09 – 72.11 Mb
Chr 8:
112.46 – 112.47 Mb
PubMed search [1] [2]

Haptoglobin-related protein is a protein that in humans is encoded by the HPR gene.[1][2][3] The HPR gene affects hereditary immunity to a non-pathogenic species of African trypanosomes.[4]

See also [link]

References [link]

  1. ^ Maeda N (Jul 1985). "Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element". J Biol Chem 260 (11): 6698–709. PMID 2987228. 
  2. ^ Nielsen MJ, Petersen SV, Jacobsen C, Oxvig C, Rees D, Moller HJ, Moestrup SK (Oct 2006). "Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein". Blood 108 (8): 2846–9. DOI:10.1182/blood-2006-05-022327. PMID 16778136. 
  3. ^ "Entrez Gene: HPR haptoglobin-related protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3250. 
  4. ^ Smith AB, Esko JD, Hajduk SL (1995). "Killing of trypanosomes by the human haptoglobin-related protein.". Science 268 (5208): 284–6. DOI:10.1126/science.7716520. PMID 7716520. 

Further reading [link]


https://wn.com/HPR_(gene)

ANSI escape code

In computing, ANSI escape codes (or escape sequences) are a method using in-band signaling to control the formatting, color, and other output options on video text terminals. To encode this formatting information, certain sequences of bytes are embedded into the text, which the terminal looks for and interprets as commands, not as character codes.

ANSI codes were introduced in the 1970s and became widespread in the minicomputer/mainframe market by the early 1980s. They were used by the nascent bulletin board system market to offer improved displays compared to earlier systems lacking cursor movement, leading to even more widespread use.

Although hardware text terminals have become increasingly rare in the 21st century, the relevance of the ANSI standard persists because most terminal emulators interpret at least some of the ANSI escape sequences in the output text. One notable exception is the win32 console component of Microsoft Windows.

History

Almost all manufacturers of video terminals added vendor-specific escape sequences to perform operations such as placing the cursor at arbitrary positions on the screen. One example is the VT52 terminal, which allowed the cursor to be placed at an x,y location on the screen by sending the ESC character, a y character, and then two characters representing with numerical values equal to the x,y location plus 32 (thus starting at the ASCII space character and avoiding the control characters).

Heparanase

Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides.

Synthesis and structure

The protein is originally synthesised in an inactive 65 kDa proheparanase form in the golgi apparatus and transferred to late endosomes/lysosomes for transport to the cell-surface. In the lysosome it is proteolytically processed into its active form. Proteolytic processing results in the production of three products,

  • a linker peptide
  • an 8 kDa proheparanase fragment and
  • a 50 kDa proheparanase fragment
  • The 8 kDa and 50 kDa fragments form a heterodimer and it is this heterodimer that constitutes the active heparanase molecule. The linker protein is so called because prior to its excision it physically links the 8 kDa and 50 kDa proheparanase fragments. Complete excision of the linker peptide appears to be a prerequisite to the complete activation of the heparanase enzyme.

    Gene

    A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.

    Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.

    Eugene (given name)

    Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

    Male foreign-language variants include:

    Notable people

    Christianity

  • Pope Eugene I, pope from 655 to 657
  • Pope Eugene II, pope from 824 to 827
  • Pope Eugene III, pope from 1145 to 1153
  • Pope Eugene IV, pope from 1431 to 1447
  • Charles-Joseph-Eugene de Mazenod (1782–1861), the founder of the Missionary Oblates of Mary Immaculate
  • St. Eugene, one of the deacons of Saint Zenobius
  • Saint Eugenios of Trebizond was the patron saint of the Empire of Trebizond
  • Pope Pius XII, pope from 1939 to 1958, given name Eugenio Maria Giuseppe Giovanni Pacelli
  • Eugene Antonio Marino (1934–2000), first African-American archbishop in the United States
  • Eugênio de Araújo Sales (1920–2012), Roman Catholic cardinal from Brazil
  • Military

  • Eugène de Beauharnais (1781–1824), the stepson and adopted child of Napoleon
  • Gene (novel)

    Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

    Characters

    Cyclades (born circa 1300 BC)

    Incarnations of Cyclades

  • Detective James North (2004 AD)
  • Eugene Dybbuk (2004 AD)
  • Aquilo (75 AD)
  • Aisha (2004)
  • William Porter (2004)
  • Athanatos (born circa 1500 BC)

    Incarnations of Athanatos

  • Detective James North (2004 AD)
  • Eugene Dybbuk (2004 AD)
  • Savage (2004 AD)
  • Podcasts:

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