| Homeobox C5 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | HOXC5; CP11; HOX3; HOX3D | ||||||||||||
| External IDs | OMIM: 142973 MGI: 96196 HomoloGene: 41296 GeneCards: HOXC5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3222 | 15424 | |||||||||||
| Ensembl | ENSG00000172789 | ENSMUSG00000022485 | |||||||||||
| UniProt | Q00444 | P32043 | |||||||||||
| RefSeq (mRNA) | NM_018953.2 | NM_175730.5 | |||||||||||
| RefSeq (protein) | NP_061826.1 | NP_783857.1 | |||||||||||
| Location (UCSC) | Chr 12: 54.38 – 54.43 Mb |
Chr 15: 102.84 – 102.85 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.[1][2][3]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only.[3]
References [link]
- ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. DOI:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. DOI:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ^ a b "Entrez Gene: HOXC5 homeobox C5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3222.
Further reading [link]
- Arcioni L, Simeone A, Guazzi S, et al. (1992). "The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins". EMBO J. 11 (1): 265–77. PMC 556447. PMID 1346761. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=556447.
- Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. DOI:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335308.
- Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. PMID 2576652.
- Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. DOI:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387083.
- Simeone A, Pannese M, Acampora D, et al. (1988). "At least three human homeoboxes on chromosome 12 belong to the same transcription unit". Nucleic Acids Res. 16 (12): 5379–90. DOI:10.1093/nar/16.12.5379. PMC 336773. PMID 2898768. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=336773.
- Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. PMC 395231. PMID 7913891. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395231.
- Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. DOI:10.1159/000134320. PMID 8646877.
- Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. DOI:10.1002/tera.10009. PMID 11857506.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
External links [link]
- HOXC5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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