Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.[1][2][3]
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.[3]
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See also [link]
Interactions [link]
HOXB9 has been shown to interact with BTG2[4] and BTG1.[4]
References [link]
- ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. DOI:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. DOI:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ^ a b "Entrez Gene: HOXB9 homeobox B9". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3219.
- ^ a b Prévôt, D; Voeltzel T, Birot A M, Morel A P, Rostan M C, Magaud J P, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. (UNITED STATES) 275 (1): 147–53. DOI:10.1074/jbc.275.1.147. ISSN 0021-9258. PMID 10617598.
Further reading [link]
- Deguchi Y, Kehrl JH (1991). "Selective expression of two homeobox genes in CD34-positive cells from human bone marrow.". Blood 78 (2): 323–8. PMID 1712647.
- Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. DOI:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
- Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. DOI:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
- Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. DOI:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335308.
- Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. PMID 2576652.
- Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. DOI:10.1159/000134320. PMID 8646877.
- Ohnishi K, Tobita T, Sinjo K, et al. (1999). "Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation". Leuk. Lymphoma 31 (5–6): 599–608. DOI:10.3109/10428199809057620. PMID 9922051.
- Prévôt D, Voeltzel T, Birot AM, et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. DOI:10.1074/jbc.275.1.147. PMID 10617598.
- Calvo R, West J, Franklin W, et al. (2001). "Altered HOX and WNT7A expression in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12776–81. DOI:10.1073/pnas.97.23.12776. PMC 18840. PMID 11070089. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18840.
- de Pinieux G, Legrier ME, Poirson-Bichat F, et al. (2001). "Clinical and Experimental Progression of a New Model of Human Prostate Cancer and Therapeutic Approach". Am. J. Pathol. 159 (2): 753–64. DOI:10.1016/S0002-9440(10)61746-4. PMC 1850557. PMID 11485933. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850557.
- Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX Homeodomain Proteins Block CBP Histone Acetyltransferase Activity". Mol. Cell. Biol. 21 (21): 7509–22. DOI:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99922.
- Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. DOI:10.1002/tera.10009. PMID 11857506.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of Insulin-Producing Cells from Human Neural Progenitor Cells". PLoS Med. 2 (4): e103. DOI:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1087208.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
External links [link]
- HOXB9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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