HOXB4

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.