HOXA3

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.

Regulation

The HOXA3 gene is repressed by the microRNA miR-10a.

See also

  • Homeobox
  • References

    Further reading

    External links

  • HOXA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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