| High mobility group nucleosomal binding domain 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | HMGN4; HMG17L3; NHC | ||||||||||||
| External IDs | MGI: 3708112 HomoloGene: 105484 GeneCards: HMGN4 Gene | ||||||||||||
|
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10473 | 633596 | |||||||||||
| Ensembl | ENSG00000182952 | n/a | |||||||||||
| UniProt | O00479 | n/a | |||||||||||
| RefSeq (mRNA) | NM_006353.2 | XM_001472085 | |||||||||||
| RefSeq (protein) | NP_006344.1 | XP_913126 | |||||||||||
| Location (UCSC) | Chr 6: 26.54 – 26.55 Mb |
n/a | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
High mobility group nucleosome-binding domain-containing protein 4 is a transcription factor that in humans is encoded by the HMGN4 gene.[1][2]
Contents |
Function [link]
The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[1]
See also [link]
References [link]
- ^ a b "Entrez Gene: high mobility group nucleosomal binding domain 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10473.
- ^ Birger Y, Ito Y, West KL, Landsman D, Bustin M (May 2001). "HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene". DNA Cell Biol. 20 (5): 257–64. DOI:10.1089/104454901750232454. PMID 11410162.
Further reading [link]
- Ruddy DA, Kronmal GS, Lee VK, et al. (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus.". Genome Res. 7 (5): 441–56. DOI:10.1101/gr.7.5.441. PMID 9149941.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
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This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it. |
https://wn.com/HMGN4
Human Genome Organisation
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world. The HUGO Gene Nomenclature Committee (HGNC), sometimes referred to as "HUGO", is one of HUGO's most active committees and aims to assign a unique gene name and symbol to each human gene.
History
HUGO was established in late April 1988 at the first meeting dedicated to genome mapping at Cold Spring Harbor. The idea of starting the organization stemmed from a South African biologist by the name of Sydney Brenner, who is known for his significant contributions to work on the genetic code and other areas of molecular biology, as well as winning the Nobel prize in Physiology of Medicine in 2002. A Founding Council was elected at the meeting that total 42 scientists from 17 different countries. HUGO is grounded in Geneva Switzerland, and later went on to elect an additional 178 members, bringing the total up to 220.
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