HLA-DQ4
HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively.
Serotype
Haplotypes
DQ4.3
DQA1*0303:DQB1*0401 is linked to DRB1*0405 and is common on the west Pacific rim, from Indonesia to Japan and inland areas of Eastern Asia. In Japan it confers susceptibility to juvenile diabetes likely via the DR4 gene.
DQA1*0303:DQB1*0402 is primarily found in Northeastern Asia and the west Pacific rim. It is similar to DQA1*0303:DQB1*0402.
DQ4.2
DQB1*0401:DQB1*0402 has a trimodal global distribution. The highest frequencies are found in the highland regions of the new world, peaking in NW Mexico and in the Andes. It is also found at high levels in Namibia and Botswana. Between these two population it is moderatedly high in the Ainu of northern Japan.
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So Happy I Could Die
by: Lady GagaEh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
I love that lavender blonde
The way she moves, the way she walks
I touch myself, can't get enough
And in the silence of the night
Through all the tears and all the lies
I touch myself, and it's alright
Just give in, don't give up, baby
Open up your heart and your mind to me
Just know when that glass is empty
That the world is gonna bend, yeah
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die, and it's alright
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
I am as vain as I allow
I do my hair, I gloss my eyes
I touch myself all through the night
And when something falls out of place
I take my time, I put it back
I touch myself 'til I'm on track
Just give in, don't give up, baby
Open up your heart and your mind to me
Just know when that glass is empty
That the world is gonna bend, yeah
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die and it's alright
So happy I could die, and it's alright
So happy I could die, and it's alright
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die, and it's alright
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever