HLA-DQ3
HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2. While the DQ3 molecules are structurally similar in beta chain, the DQ molecules differ markedly in function, even when present with the same DQ alpha subunit. For this reason they are best treated independently.
Serology
The serotyping efficiency of DQ3 recognition relative to DQ2, DQ7, DQ8, and DQ9 is shown to the left. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ3 recognition is relatively low and error prone. This compares to genotyping efficiency of 100%. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DBB1*group recognizes DQB1*0303 as efficiently as DQ3.
For this reason DQ3 serotyping is a poor method of typing for transplantation or disease association prediction or study. Nonetheless, it is still widely used and association purported in the literature.
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So Happy I Could Die
by: Lady GagaEh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
I love that lavender blonde
The way she moves, the way she walks
I touch myself, can't get enough
And in the silence of the night
Through all the tears and all the lies
I touch myself, and it's alright
Just give in, don't give up, baby
Open up your heart and your mind to me
Just know when that glass is empty
That the world is gonna bend, yeah
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die, and it's alright
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
I am as vain as I allow
I do my hair, I gloss my eyes
I touch myself all through the night
And when something falls out of place
I take my time, I put it back
I touch myself 'til I'm on track
Just give in, don't give up, baby
Open up your heart and your mind to me
Just know when that glass is empty
That the world is gonna bend, yeah
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die and it's alright
So happy I could die, and it's alright
So happy I could die, and it's alright
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die, and it's alright
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever