HLA-DQ1
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.
Serotypes
The serotyping efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed below. Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6.
The table to the left shows some of the serotyping efficiencies. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ1 recognition is relatively low and error prone.
Podcasts:
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So Happy I Could Die
by: Lady GagaEh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
I love that lavender blonde
The way she moves, the way she walks
I touch myself, can't get enough
And in the silence of the night
Through all the tears and all the lies
I touch myself, and it's alright
Just give in, don't give up, baby
Open up your heart and your mind to me
Just know when that glass is empty
That the world is gonna bend, yeah
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die, and it's alright
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
I am as vain as I allow
I do my hair, I gloss my eyes
I touch myself all through the night
And when something falls out of place
I take my time, I put it back
I touch myself 'til I'm on track
Just give in, don't give up, baby
Open up your heart and your mind to me
Just know when that glass is empty
That the world is gonna bend, yeah
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die and it's alright
So happy I could die, and it's alright
So happy I could die, and it's alright
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Eh-eh, eh-eh, yeha, yeha
Eh-eh, eh-eh, aha, aha
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever
Eh-eh, eh-eh, so happy I could die, and it's alright
Happy in the club with a bottle of red wine
Stars in our eyes 'cause we're having a good time
Eh-eh, eh-eh, so happy I could die
Be your best friend, yeah, I'll love you forever
Up in the clouds, we'll be higher than ever