HHV Latency Associated Transcript

HHV Latency Associated Transcript (HHV LAT) is a length of RNA which accumulates in cells hosting long-term, or latent, Human Herpes Virus (HHV) infections. The LAT RNA is produced by genetic transcription from a certain region of the viral DNA. LAT regulates the viral genome and interferes with the normal activities of the infected host cell.

Herpes virus may establish lifelong infection during which a reservoir virus population survives in host nerve cells for long periods of time. Such long-term Herpes infection requires a mode of cellular infection known as latent infection. During the latent infection, the metabolism of the host cell is disrupted. While the infected cell would ordinarily undergo an organized death or be removed by the immune system, the consequences of LAT production interfere with these normal processes.

Latency is distinguished from lytic infection; in lytic infection many Herpes virus particles are produced and then burst or lyse the host cell. Lytic infection is sometimes known as "productive" infection. Latent cells harbor the virus for long time periods, then occasionally convert to productive infection which may lead to a recurrence of symptomatic Herpes symptoms.

.lat

.lat is a proposed Internet generic top-level domain (gTLD) for Latin American communities and users wherever they may reside.

Recently NIC México (Manager of the .mx ccTLD) along with eCOM-LAC (Federation of Latin-America and the Caribbean for the Internet and Electronic Commerce) were appointed official sponsors for this campaign. The full proposal was supposed to be presented to ICANN during 2008 but the new gTLD process in ICANN has been delayed and now it is expected to be presented by mid-2011.

There were initial communications that presented the idea of this new top-level domain as a regional one but further news detailed the community orientation of the proposal

The official gTLD name will be appointed by ICANN if the proposal is approved. Other names that are being considered are .latin and .latino. Similar proposals have already been approved like the Asian gTLD (.asia) and the European Union's ccTLD (.eu).

References

Lat.

Lat. or lat. is an abbreviation for:

Lat

Datuk Mohammad Nor Khalid (Jawi: محمد نور خالد), more commonly known as Lat, (born 5 March 1951) is a Malaysian cartoonist. Winner of the Fukuoka Asian Culture Prize in 2002, Lat has published more than 20 volumes of cartoons since he was 13 years old. His works mostly illustrate Malaysia's social and political scenes, portraying them in a comedic light without bias. Lat's best known work is The Kampung Boy (1979), which is published in several countries across the world. In 1994, the Sultan of Perak bestowed the honorific title of datuk on Lat, in recognition of the cartoonist's work in helping to promote social harmony and understanding through his cartoons.

Born in a village, Lat spent his youth in the countryside before moving to the city at the age of 11. While in school, he supplemented his family's income by contributing cartoon strips to newspapers and magazines. He was 13 years old when he achieved his first published comic book, Tiga Sekawan (Three Friends Catch a Thief). After failing to attain the grades that were required to continue education beyond high school, Lat became a newspaper reporter. In 1974, he switched careers to be an editorial cartoonist. His works, reflecting his view about Malaysian life and the world, are staple features in national newspapers such as New Straits Times and Berita Minggu. He adapted his life experiences and published them as his autobiographies, The Kampung Boy and Town Boy, telling stories of rural and urban life with subtle comparisons between the two.