HDAC8
Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene.
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation / deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
Histone deacetylase 8 is involved in skull morphogenesis and metabolic control of the ERR-alpha / PGC1-alpha transcriptional complex.
Clinical significance
HDAC8 has been linked to number of disease states notably to acute myeloid leukemia and is related to actin cytoskeleton in smooth muscle cells. siRNA targeting HDAC8 showed anticancer effects. Inhibition of HDAC8 induced apoptosis has been observed in T cell lymphomas. In addition the HDAC8 enzyme has been implicated in the pathogenesis of neuroblastoma. Therefore, there has been interest in developing HDAC8 selective inhibitors.
Podcasts:
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by TG4
Virginity
by: TG4I know you want it
You wanna hit it
But you can't have it
Oops, can't touch it
Maybe a kiss on these lips
Holding hands it aint nothing
Nasty is what you call me
We get close but you can't handle it
Cuz I'm not maybe what your looking
Cuz I'm not the average kind of girl
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Can't imagine what it feels like
My friends say it's alright
But then they go and do it all night
But I prefer the merry life
Patience is what you gotta have
That's what it takes to be my man
I'm not like that bad if you like me
Keep it with you then maybe
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
God D@^^* what part don't you understand
The N or the O
You get nothing from TG4
Let it go
Here we go
With the everyday scenario
Jeans painted on cleavage showin
Dont mean she easy
Girl you gotta keep your integrity
I wouldn't let him get over on me
Dont fall for the same game
Him callin you boo
Telling you he love you
And everything he gone do
Treat your body like a temple
The best thing ever made
Cuz once you let him hit
Watch how those feelings fade away
You gotta be the best at this game being played
Dont give it up know
Some things are better off saved
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me