HDAC3
Histone deacetylase 3 is an enzyme that in humans is encoded by the HDAC3 gene.
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
This enzyme is involved in the coordination of commensal-bacteria-dependent intestinal homeostasis when expressed in intestinal epithelial cells.
Alternative functions
Histone deacetylases can be regulated by endogenous factors, dietary components, synthetic inhibitors and bacteria-derived signals. Studies in mice with a specific deletion of HDAC3 in intestinal epithelial cells (IECs) show a deregulated IEC’s gene expression. In these deletion-mutant mice, loss of Paneth cells, impaired IEC function and alterations in intestinal composition of commensal bacteria were observed. These negative effects were not observed in germ-free mice, indicating that the effects of the deletion are only seen in the presence of intestinal microbial colonization. But the negative effects of HDAC3 deletion are not due to the presence of an altered microbiota because normal germ-free mice colonized with the altered microbiota did not show the negative effects seen in deletion mutants.
Podcasts:
-
by TG4
Virginity
by: TG4I know you want it
You wanna hit it
But you can't have it
Oops, can't touch it
Maybe a kiss on these lips
Holding hands it aint nothing
Nasty is what you call me
We get close but you can't handle it
Cuz I'm not maybe what your looking
Cuz I'm not the average kind of girl
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Can't imagine what it feels like
My friends say it's alright
But then they go and do it all night
But I prefer the merry life
Patience is what you gotta have
That's what it takes to be my man
I'm not like that bad if you like me
Keep it with you then maybe
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
Baby its not like I dont really like you
You just gotta know
That if your not willing to get with my loving
Than you've gotta go
God D@^^* what part don't you understand
The N or the O
You get nothing from TG4
Let it go
Here we go
With the everyday scenario
Jeans painted on cleavage showin
Dont mean she easy
Girl you gotta keep your integrity
I wouldn't let him get over on me
Dont fall for the same game
Him callin you boo
Telling you he love you
And everything he gone do
Treat your body like a temple
The best thing ever made
Cuz once you let him hit
Watch how those feelings fade away
You gotta be the best at this game being played
Dont give it up know
Some things are better off saved
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me