HDAC11
Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice.
It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II. It is the smallest HDAC isoform and it was first described in 2002.
Function
Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.[supplied by OMIM]
HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells.
HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.
Interactions
Podcasts:
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
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by Tech N9ne
Hard Liquor
by: Tech N9ne[Chorus]
Hard liquor
Me and my people be so drunk we don't drive
We take the trolley ‘cause of hard liquor,
We started Waldo to Westport and pee in every martini corner at the last call
And we all yellin' “Is there any more?”
When it ain't we go home for hard liquor,
Make sure that it's mixed, yeah
And twist it with a little bit of lemon juice on ice, on ice, on ice, yeahhh.
[Tech N9ne]
Aye aye they sayin' that I got high blood sugar,
So I can't drink like I wanna drink, drink like I wanna know
I ain't playin ‘cause I love liquor
So if I big drink am I gonna drink, jinxed, I don't wanna go,
So I go hard as hell on one night, fun sight
If I'm drunk enough to start a bum fight
Done right, Henny, Jack and Gin, 151 Rum slight, none light
Novocain I know to blame a gun snipe on drunk life
then the bar hit ya with a large spritzer
Hit ya ass, get ya cash then they all richer
in the draw, pitcher
I'm large sipper
When you wait, but I hope I ain't in the car witcha.
[Eminem]
What the fuck?
Ey yo Whoo Kid!
Run that shit back!
Goddamn!
[Chorus]
Hard liquor
Me and my people be so drunk we don't drive
We take the trolley ‘cause of hard liquor,
We started Waldo to Westport and pee in every martini corner at the last call
And we all yellin' “Is there any more?”
When it ain't we go home for hard liquor,
Make sure that it's mixed, yeah
And twist it with a little bit of lemon juice on ice, on ice, on ice, yeahhh.
[Tech N9ne]
Aye aye they sayin' that I got high blood sugar,
So I can't drink like I wanna drink, drink like I wanna know
I ain't playin ‘cause I love liquor
So if I big drink am I gonna drink, jinxed, I don't wanna go,
So I go hard as hell on one night, fun sight
If I'm drunk enough to start a bum fight
Done right, Henny, Jack and Gin, 151 Rum slight, none light
Novocain I know to blame a gun snipe on drunk life
then the bar hit ya with a large spritzer
Hit ya ass, get ya cash then they all richer
in the draw, pitcher
I'm large sipper
When you wait, but I hope I ain't in the car witcha.
Hard liquor, I need some more, hard liquor
all the alcoholics in this
is there any more
We even go to WalMart for (hard liquor)
Make sure that it's mixed
And twist it with a little bit of lemon juice on ice, on ice, on ice, yeahhh
Hard liquor, hard liquor
Is there any more?
Hard liquor
Make sure that it's mixed