Collision-induced dissociation

Collision-induced dissociation (CID), also known as collisionally activated dissociation (CAD), is a mass spectrometry technique to induce fragmentation of molecular ions in the gas phase. The molecular ions are usually accelerated by some electrical potential to high kinetic energy and then allowed to collide with neutral molecules (often helium, nitrogen or argon). In the collision some of the kinetic energy is converted into internal energy which results in bond breakage and the fragmentation of the molecular ion into smaller fragments. These fragment ions can then be analyzed by a tandem mass spectrometry.

CID and the fragment ions produced by CID are used for several purposes. Partial or complete structural determination can be achieved. In some cases identity can be established based on previous knowledge without determining structure. Another use is in simply achieving more sensitive and specific detection. By detecting a unique fragment ion, the precursor ion can be detected in the presence of other ions of the mass to charge ratio, reducing the background and increasing the limit of detection.

HCD

HCD may stand for:

  • Higher-energy collisional dissociation, an ion fragmentation technique
  • Hectocandela, an SI unit of luminous intensity equal to 100 candelas
  • Host controller driver, a host controller interface
  • HCD Research, developers of MediaCurves
  • The Swiss ice hockey club HC Davos
  • The California state agency, the California Department of Housing and Community Development
  • Podcasts:

    PLAYLIST TIME:

    Sleepwalking

    by: Kittie

    Watching me fall
    Into the flames
    Of a broken soul tonight
    No stone overturned
    This graveyard of mine
    Allows me no peace
    [Chorus]
    Sleep as day dies
    Sleepwalk with the dead
    Wander aimlessly through the night
    Love and regret
    Course through my veins
    As I slowly fade away
    Please let me sleep
    Just one last night
    Before I must wake
    [Chorus]
    And I walk with these ghosts
    And I walk with these ghosts
    And I walk with these ghosts...
    [Chorus]
    Sleep as night falls
    Sleepwalk with the dead
    Hope keeps me alive




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