HBI-3000 (sulcardine sulfate) is an experimental drug candidate that is currently in phase II of human clinical trials as an antiarrhythmic agent. Clinical investigation will test the safety and efficacy of HBI-3000 as a treatment for both atrial and ventricular arrhythmias.
Anti-arrhythmic medication is taken to treat irregular beating of the heart. This irregular beating results from a deregulation of the initiation or propagation of the electrical stimulus of the heart. The most common chronic arrhythmia is atrial fibrillation. There is an increased incidence of atrial fibrillation in the elderly and some examples of complications include heart failure exacerbation, hypotension and thrombembolic events.
Most anti-arrhythmic medications exert their effects by decreasing the permeability of potassium ion channels (IKr) in heart cells. These potassium channel blockers delay ventricular repolarization and prolong action potential duration (APD; the prolongation of the electrical stimulus within heart cells). These changes can lower heart rate, eliminate atrial fibrillation, and ultimately sudden cardiac death.
Tomorrow's coming 'round
A hair-pin curve in the road
She's got a run in her stocking
And she's missing the heel of her shoe
Got up this morning rolled out of bed
I spilled a diet coke
Called my mother said, "Hi"
What I meant to say was, "Why is your life a joke?"
Then, I went down to that ugly bar and
I clicked my heels three times just like you said
And I climbed that road to your empty house
The anticipation was a turn on
But you let me down
'Coz, I stood on that empty street alone
I said, "I'm ready for my close up now, Mr. Demille"
I waited for the light, but it never shone
Well I wonder what you do with that expensive piece of land
That overlooks a billion years of history
I have a sneaking suspicion, you will never understand
Hey maybe I'll see you down by the Rocky and Bullwinkle
And we can talk to that charlatan psychic
And she can paint a prettier picture of your future
'Coz that day in my life, that day in my life
I dreamt tomorrow, had a prettier face
I dreamt tomorrow, would have better things to say
Than, "You look like shit, what's your problem, bitch?
You're legs feel like sandpaper, you can't do anything right"
'Coz that day, never should have taken place
'Coz this day, in my life still cannot explain
Why I listened in the first place to you?
Oh yeah, something else
I hope one day you call up your father
And you have the guts to tell him, how he hurt you
And he made you hurt another