HBI-3000

HBI-3000 (sulcardine sulfate) is an experimental drug candidate that is currently in phase II of human clinical trials as an antiarrhythmic agent. Clinical investigation will test the safety and efficacy of HBI-3000 as a treatment for both atrial and ventricular arrhythmias.

The molecular problem

Anti-arrhythmic medication is taken to treat irregular beating of the heart. This irregular beating results from a deregulation of the initiation or propagation of the electrical stimulus of the heart. The most common chronic arrhythmia is atrial fibrillation. There is an increased incidence of atrial fibrillation in the elderly and some examples of complications include heart failure exacerbation, hypotension and thrombembolic events.

Most anti-arrhythmic medications exert their effects by decreasing the permeability of potassium ion channels (IKr) in heart cells. These potassium channel blockers delay ventricular repolarization and prolong action potential duration (APD; the prolongation of the electrical stimulus within heart cells). These changes can lower heart rate, eliminate atrial fibrillation, and ultimately sudden cardiac death.

HB-F9P

The HB-F9P was a Sony MSX2-computer, launched in 1985. The abbreviation HB stands for Hit Bit.

The HB-F9P was unusual in the sense that it did not come with a built in floppy disk drive, instead it had a built in software suite "Memovision" that would run automatically unless a program cartridge was inserted in the cartridge slot or the GRAPH key was pressed during booting. Memovision could store data on the special HBI-55 (battery backed RAM) "data cartridge" that Sony originally had developed, for their HB-55 and HB-75 MSX1 computers. These systems contained a simple built in program called the "Personal Databank". Memovision was a continuation of the same idea, but much extended, as it contained stuff like a (birthday) calendar with alarm system, a "family databank" (a combination of a text editor and database) a built in calculator and a timer and time calculator, all rendered in pseudo 3D style.

Variants

Of the HB-F9 there were many different localized variants produced:

HBI

HBI may refer to: