Hemoglobin, alpha 2 also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin.
The human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb, including seven alpha like globin genes and pseudogenes: 5'- HBZ - HBZP1 - HBM - HBAP1 - HBA2 - HBA1 - HBQ1 -3'. The HBA2 (α2) and HBA1 (α1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions.
Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin.
Alpha-thalassemias most commonly result from deletions of any of the four alpha genes, although some alpha thalassemias have been reported that are due to mutations other than deletion. Deletion of 1 or 2 alleles is clinically silent. Deletion of 3 alleles causes HbH disease, resulting in anemia and hepatosplenomegaly. Deletion of all 4 alleles is lethal because it renders the body unable to make fetal hemoglobin (HbF), adult hemoglobin (HbA) or adult variant hemoglobin (HbA2), and results in hydrops fetalis.
Tomorrow's coming 'round
A hair-pin curve in the road
She's got a run in her stocking
And she's missing the heel of her shoe
Got up this morning rolled out of bed
I spilled a diet coke
Called my mother said, "Hi"
What I meant to say was, "Why is your life a joke?"
Then, I went down to that ugly bar and
I clicked my heels three times just like you said
And I climbed that road to your empty house
The anticipation was a turn on
But you let me down
'Coz, I stood on that empty street alone
I said, "I'm ready for my close up now, Mr. Demille"
I waited for the light, but it never shone
Well I wonder what you do with that expensive piece of land
That overlooks a billion years of history
I have a sneaking suspicion, you will never understand
Hey maybe I'll see you down by the Rocky and Bullwinkle
And we can talk to that charlatan psychic
And she can paint a prettier picture of your future
'Coz that day in my life, that day in my life
I dreamt tomorrow, had a prettier face
I dreamt tomorrow, would have better things to say
Than, "You look like shit, what's your problem, bitch?
You're legs feel like sandpaper, you can't do anything right"
'Coz that day, never should have taken place
'Coz this day, in my life still cannot explain
Why I listened in the first place to you?
Oh yeah, something else
I hope one day you call up your father
And you have the guts to tell him, how he hurt you
And he made you hurt another