H2AFX
H2AFX (H2A histone family, member X) is one of several genes coding for histone H2A. In humans and other eukaryotes, the DNA is wrapped around histone-groups, consisting of core histones H2A, H2B, H3 and H4. Thus, the H2AX contributes to the nucleosome-formation and therefore the structure of DNA.
H2AX becomes phosphorylated on serine 139, then called gamma-H2AX, as a reaction on DNA Double-strand breaks (DSB). The kinases of the PI3-family (Ataxia telangiectasia mutated, ATR and DNA-PKcs) are responsible for this phosphorylation, especially ATM. The modification can happen accidentally during replication fork collapse or in the response to ionizing radiation but also during controlled physiological processes such as V(D)J recombination. Gamma-H2AX is a sensitive target for looking at DSBs in cells. The role of the phosphorylated form of the histone in DNA repair is under discussion but it is known that because of the modification the DNA becomes less condensed, potentially allowing space for the recruitment of proteins necessary during repair of DSBs. Mutagenesis experiments have shown that the modification is necessary for the proper formation of ionizing radiation induced foci in response to double strand breaks, but is not required for the recruitment of proteins to the site of DSBs.
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by Kyuss
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by Kaci
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2000 MAN
by: KissWell, my name it is a number it's on a piece of plastic film
And I've been growin' funny flowers outside on my little window sill
Don't you know I'm a 2,000 man
And my kids, they just don't understand me at all
You know, my wife still respects me even though I really misuse her
I am having an affair with the Random computer
Don't you know I'm a 2,000 man
And my kids, they just don't understand me at all
Oh daddy, proud of your planet, oh mommy, proud of your sun
Oh daddy, proud of your planet, oh mommy, proud of your sun
Oh daddy, your brain's still flashin' like they did when you were young
Or did they come down crashin' seeing all the thing's you'd done
Spacin' out havin' fun
Oh daddy, proud of your planet, oh mommy, proud of your sun
Oh daddy, proud of your planet, oh mommy, proud of your sun
Oh daddy, your brain's still flashin' like they did when you were young
Or did they come down crashin' seeing all the thing's you'd done
Spacin' out havin' fun
Don't you know I'm a 2,000 man
And my kids, they just don't understand me at all
Don't you know I'm a 2,000 man
And my kids, they just don't understand me at all
Understand me, understand me, understand me
Don't you know I'm a 2,000 man
And my kids, they just don't understand me at all
Don't you know I'm a 2,000 man
And my kids, they just don't understand me at all
I'm a 2,000 man, I'm a 2,000 man
I'm a 2,000 man, I'm a 2,000 man