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Tropisetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. The drug is available in a 5 mg oral preparation or in 2 mg intravenous form. It is marketed by Novartis in Europe, Australia, New Zealand, Japan, South Korea and the Philippines as Navoban, but is not available in the U.S. It is also available from Novell Pharmaceutical Laboratories and marketed in several Asian countries as Setrovel.
Tropisetron acts as both a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist.
Tropisetron is a well-tolerated drug with few side effects. Headache, constipation, and dizziness are the most commonly reported side effects associated with its use. Hypotension, transient liver enzyme elevation, immune hypersensitivity syndromes and extrapyramidal side effects have also been associated with its use on at least one occasion.There have been no significant drug interactions reported with this drug's use. It is broken down by the hepatic cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system.
A ICS Form 219, Resource Status Card or T-Card, is a simple tool to record and track the location and status of individuals, teams, vehicles, and other equipment. It is part of the standardised Incident Command System now widely used by police, fire departments, and emergency management agencies to manage their responses to incidents.
The cards are so-named because they are made of card stock and have a T-like shape. These cards are displayed in resource status or “T-Card racks” (typically a sheet of plastic or metal with slots cut to accept the body of the card) where they can be easily viewed, retrieved, updated, and statused during the course of the incident.
Each card is printed in a different color of card stock and used for a different resource category, kind, or type: