Gtf2h1

General transcription factor IIH, polypeptide 1, 62kDa

PDB rendering based on 1pfj.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1PFJ, 2DII, 2RNR

Identifiers

Symbols

GTF2H1; BTF2; TFB1; TFIIH

External IDs

OMIM: 189972 MGI: 1277216 HomoloGene: 3885 GeneCards: GTF2H1 Gene

Gene Ontology
Molecular function	• protein kinase activity • protein binding • DNA-dependent ATPase activity • RNA polymerase II carboxy-terminal domain kinase activity
Cellular component	• nucleus • nucleoplasm • holo TFIIH complex
Biological process	• regulation of cyclin-dependent protein kinase activity • nucleotide-excision repair, DNA damage removal • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • regulation of transcription, DNA-dependent • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • mRNA capping • protein phosphorylation • gene expression • viral reproduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of viral transcription
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
18.34 – 18.39 Mb

Chr 7:
54.05 – 54.08 Mb

PubMed search

[1]

[2]

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.^[1]^[2]^[3]

1 Interactions
2 See also
3 References
4 Further reading
5 External links

Interactions [link]

GTF2H1 has been shown to interact with E2F1,^[4] XPB,^[5]^[6]^[7] ERCC2,^[7]^[8] Estrogen receptor alpha,^[9] Cyclin-dependent kinase 7^[7]^[10]^[11] and TCEA1.^[12]^[13]

References [link]

^ Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science 257 (5075): 1392–5. DOI:10.1126/science.1529339. PMID 1529339.
^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum Mol Genet 3 (1): 61–4. DOI:10.1093/hmg/3.1.61. PMID 8162052.
^ "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2965.
^ Vandel, L; Kouzarides T (August 1999). "Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase". EMBO J. (ENGLAND) 18 (15): 4280–91. DOI:10.1093/emboj/18.15.4280. ISSN 0261-4189. PMC 1171504. PMID 10428966. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171504.
^ Giglia-Mari, Giuseppina; Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wim (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. (United States) 36 (7): 714–9. DOI:10.1038/ng1387. ISSN 1061-4036. PMID 15220921.
^ Marinoni, J C; Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez D M, Hoeijmakers J H, Egly J M (March 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. (ENGLAND) 16 (5): 1093–102. DOI:10.1093/emboj/16.5.1093. ISSN 0261-4189. PMC 1169708. PMID 9118947. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169708.
^ ^a ^b ^c Rossignol, M; Kolb-Cheynel I, Egly J M (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. (ENGLAND) 16 (7): 1628–37. DOI:10.1093/emboj/16.7.1628. ISSN 0261-4189. PMC 1169767. PMID 9130708. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169767.
^ Drapkin, R; Reardon J T, Ansari A, Huang J C, Zawel L, Ahn K, Sancar A, Reinberg D (April 1994). "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature (ENGLAND) 368 (6473): 769–72. DOI:10.1038/368769a0. ISSN 0028-0836. PMID 8152490.
^ Chen, D; Riedl T, Washbrook E, Pace P E, Coombes R C, Egly J M, Ali S (July 2000). "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7". Mol. Cell (UNITED STATES) 6 (1): 127–37. DOI:10.1016/S1097-2765(00)00014-9. ISSN 1097-2765. PMID 10949034.
^ Shiekhattar, R; Mermelstein F, Fisher R P, Drapkin R, Dynlacht B, Wessling H C, Morgan D O, Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature (ENGLAND) 374 (6519): 283–7. DOI:10.1038/374283a0. ISSN 0028-0836. PMID 7533895.
^ Yee, A; Nichols M A, Wu L, Hall F L, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. (UNITED STATES) 55 (24): 6058–62. ISSN 0008-5472. PMID 8521393.
^ Archambault, J; Pan G, Dahmus G K, Cartier M, Marshall N, Zhang S, Dahmus M E, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. (UNITED STATES) 273 (42): 27593–601. DOI:10.1074/jbc.273.42.27593. ISSN 0021-9258. PMID 9765293.
^ Pan, G; Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. (UNITED STATES) 272 (39): 24563–71. DOI:10.1074/jbc.272.39.24563. ISSN 0021-9258. PMID 9305922.

Further reading [link]

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription.". J. Biomed. Sci. 5 (1): 24–7. DOI:10.1007/BF02253352. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation.". Curr. Biol. 8 (13): R447–9. DOI:10.1016/S0960-9822(98)70289-1. PMID 9651670.
Shiekhattar R, Mermelstein F, Fisher RP, et al. (1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH.". Nature 374 (6519): 283–7. DOI:10.1038/374283a0. PMID 7533895.
Tong X, Drapkin R, Reinberg D, Kieff E (1995). "The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3259–63. DOI:10.1073/pnas.92.8.3259. PMC 42145. PMID 7724549. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42145.
Fantes JA, Oghene K, Boyle S, et al. (1995). "A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1.". Genomics 25 (2): 447–61. DOI:10.1016/0888-7543(95)80045-N. PMID 7789978.
Xiao H, Pearson A, Coulombe B, et al. (1994). "Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.". Mol. Cell. Biol. 14 (10): 7013–24. PMC 359231. PMID 7935417. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359231.
Schaeffer L, Moncollin V, Roy R, et al. (1994). "The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.". EMBO J. 13 (10): 2388–92. PMC 395103. PMID 8194528. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395103.
Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain.". Mol. Cell. Biol. 16 (5): 2044–55. PMC 231191. PMID 8628270. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231191.
Iyer N, Reagan MS, Wu KJ, et al. (1996). "Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.". Biochemistry 35 (7): 2157–67. DOI:10.1021/bi9524124. PMID 8652557.
Reardon JT, Ge H, Gibbs E, et al. (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. DOI:10.1073/pnas.93.13.6482. PMC 39049. PMID 8692841. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39049.
Drapkin R, Le Roy G, Cho H, et al. (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. DOI:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39050.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605–10. DOI:10.1126/science.274.5287.605. PMID 8849451.
Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.". Nature 384 (6607): 375–8. DOI:10.1038/384375a0. PMID 8934526.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.". J. Biol. Chem. 272 (11): 6951–8. DOI:10.1074/jbc.272.11.6951. PMID 9054383.
Marinoni JC, Roy R, Vermeulen W, et al. (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.". EMBO J. 16 (5): 1093–102. DOI:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169708.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232028.
Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.". EMBO J. 16 (7): 1628–37. DOI:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169767.
García-Martínez LF, Mavankal G, Neveu JM, et al. (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.". EMBO J. 16 (10): 2836–50. DOI:10.1093/emboj/16.10.2836. PMC 1169892. PMID 9184228. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169892.

PDB gallery

1pfj: Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit

2dii: Solution structure of the BSD domain of human TFIIH basal transcription factor complex p62 subunit

External links [link]

GTF2H1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLH (2, 9) · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1

(1.3) bHLH-ZIP	AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2)

(1.4) NF-1	NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)

(1.5) RF-X	RFX (1, 2, 3, 4, 5, 6, ANK)

(1.6) Basic helix-span-helix (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1

(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (11, 16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX (1, 2) · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · SIX (1, 2, 3, 4, 5) · VAX1 · ZEB (1, 2)

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2

(3.6) TEA domain	transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1, TBR2) · TP63

(4.4) MADS box	Mef2 (A, B, C, D) · SRF

(4.6) TATA binding proteins	TBP · TBPL1

(4.7) High-mobility group	BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4) · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4)

(4.9) Grainyhead	TFCP2

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) · HBP1

(0.3) Pocket domain	Rb · RBL1 · RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 · EREBP · B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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